Effect of pulsed electromagnetic fields on ovariectomized rats

Gianluca Giavaresi, Milena Fini, Saverio Gnudi, Lucia Martini, Romano Mongiorgi, Nicolò Nicoli Aldini, Allesandro Zati, Roberto Giardino

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Sixty Sprague-Dawley rats (10 months old, body weight 400 ± 25 g) were randomized into six groups of 10 animals each, to study the effect of pulsed electromagnetic fields (PEMFs) on the treatment of ovariectomized osteopenic rats. One group was used as baseline (Baseline). Four groups were ovariectomized, and another was sham-operated (Sham). Three ovariectomized groups were given three different PEMFs of the same intensity (7 mT) for 1 h a day for 16 weeks. Groups OVX-50 and OVX-100 were subjected to monodirectional sine-wave PEMFs with different frequencies (50 and 100 Hz), while Group OVX-72 was subjected to 72-Hz bidirectional square-wave PEMFs. Group Sham and an unexposed ovariectomized group (OVX) were used as therapy controls. Differences were observed for densitometric, bio- mechanical, and histomorphometric data (p <0.005), particularly between the ovariectomized groups and the non-ovariectomized groups. Monthly food consumption (MFC) showed significant decreases (p <0.05) in Groups OVX, OVX-72, and OVX-100, as monthly ponderal variation (MPV) showed significant differences (p <0.005), particularly Group OVX-72 vs. Group OVX. However, none of the PEMFs used produced an amelioration of castration-induced osteopenia by changing the balance between bone resorption and formation. As opposed to PEMFs at 50 and 100 Hz, the effect on bone of PEMFs at 72 Hz could have been hidden by systemic application of an instrument conceived for local therapy only.

Original languageEnglish
Pages (from-to)119-131
Number of pages13
JournalElectro- and Magnetobiology
Volume18
Issue number2
Publication statusPublished - 1999

Fingerprint

Electromagnetic Fields
rats
osteopenia
therapeutics
bone resorption
Metabolic Bone Diseases
Castration
castration
Bone Resorption
electromagnetic field
bone formation
Osteogenesis
food consumption
Sprague Dawley Rats
Body Weight
bones
Weights and Measures
Bone and Bones
Food
body weight

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics

Cite this

Effect of pulsed electromagnetic fields on ovariectomized rats. / Giavaresi, Gianluca; Fini, Milena; Gnudi, Saverio; Martini, Lucia; Mongiorgi, Romano; Aldini, Nicolò Nicoli; Zati, Allesandro; Giardino, Roberto.

In: Electro- and Magnetobiology, Vol. 18, No. 2, 1999, p. 119-131.

Research output: Contribution to journalArticle

@article{90deed3d1f6e478f9cd20763c581c090,
title = "Effect of pulsed electromagnetic fields on ovariectomized rats",
abstract = "Sixty Sprague-Dawley rats (10 months old, body weight 400 ± 25 g) were randomized into six groups of 10 animals each, to study the effect of pulsed electromagnetic fields (PEMFs) on the treatment of ovariectomized osteopenic rats. One group was used as baseline (Baseline). Four groups were ovariectomized, and another was sham-operated (Sham). Three ovariectomized groups were given three different PEMFs of the same intensity (7 mT) for 1 h a day for 16 weeks. Groups OVX-50 and OVX-100 were subjected to monodirectional sine-wave PEMFs with different frequencies (50 and 100 Hz), while Group OVX-72 was subjected to 72-Hz bidirectional square-wave PEMFs. Group Sham and an unexposed ovariectomized group (OVX) were used as therapy controls. Differences were observed for densitometric, bio- mechanical, and histomorphometric data (p <0.005), particularly between the ovariectomized groups and the non-ovariectomized groups. Monthly food consumption (MFC) showed significant decreases (p <0.05) in Groups OVX, OVX-72, and OVX-100, as monthly ponderal variation (MPV) showed significant differences (p <0.005), particularly Group OVX-72 vs. Group OVX. However, none of the PEMFs used produced an amelioration of castration-induced osteopenia by changing the balance between bone resorption and formation. As opposed to PEMFs at 50 and 100 Hz, the effect on bone of PEMFs at 72 Hz could have been hidden by systemic application of an instrument conceived for local therapy only.",
author = "Gianluca Giavaresi and Milena Fini and Saverio Gnudi and Lucia Martini and Romano Mongiorgi and Aldini, {Nicol{\`o} Nicoli} and Allesandro Zati and Roberto Giardino",
year = "1999",
language = "English",
volume = "18",
pages = "119--131",
journal = "Electro- and Magnetobiology",
issn = "1061-9526",
publisher = "Marcel Dekker Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of pulsed electromagnetic fields on ovariectomized rats

AU - Giavaresi, Gianluca

AU - Fini, Milena

AU - Gnudi, Saverio

AU - Martini, Lucia

AU - Mongiorgi, Romano

AU - Aldini, Nicolò Nicoli

AU - Zati, Allesandro

AU - Giardino, Roberto

PY - 1999

Y1 - 1999

N2 - Sixty Sprague-Dawley rats (10 months old, body weight 400 ± 25 g) were randomized into six groups of 10 animals each, to study the effect of pulsed electromagnetic fields (PEMFs) on the treatment of ovariectomized osteopenic rats. One group was used as baseline (Baseline). Four groups were ovariectomized, and another was sham-operated (Sham). Three ovariectomized groups were given three different PEMFs of the same intensity (7 mT) for 1 h a day for 16 weeks. Groups OVX-50 and OVX-100 were subjected to monodirectional sine-wave PEMFs with different frequencies (50 and 100 Hz), while Group OVX-72 was subjected to 72-Hz bidirectional square-wave PEMFs. Group Sham and an unexposed ovariectomized group (OVX) were used as therapy controls. Differences were observed for densitometric, bio- mechanical, and histomorphometric data (p <0.005), particularly between the ovariectomized groups and the non-ovariectomized groups. Monthly food consumption (MFC) showed significant decreases (p <0.05) in Groups OVX, OVX-72, and OVX-100, as monthly ponderal variation (MPV) showed significant differences (p <0.005), particularly Group OVX-72 vs. Group OVX. However, none of the PEMFs used produced an amelioration of castration-induced osteopenia by changing the balance between bone resorption and formation. As opposed to PEMFs at 50 and 100 Hz, the effect on bone of PEMFs at 72 Hz could have been hidden by systemic application of an instrument conceived for local therapy only.

AB - Sixty Sprague-Dawley rats (10 months old, body weight 400 ± 25 g) were randomized into six groups of 10 animals each, to study the effect of pulsed electromagnetic fields (PEMFs) on the treatment of ovariectomized osteopenic rats. One group was used as baseline (Baseline). Four groups were ovariectomized, and another was sham-operated (Sham). Three ovariectomized groups were given three different PEMFs of the same intensity (7 mT) for 1 h a day for 16 weeks. Groups OVX-50 and OVX-100 were subjected to monodirectional sine-wave PEMFs with different frequencies (50 and 100 Hz), while Group OVX-72 was subjected to 72-Hz bidirectional square-wave PEMFs. Group Sham and an unexposed ovariectomized group (OVX) were used as therapy controls. Differences were observed for densitometric, bio- mechanical, and histomorphometric data (p <0.005), particularly between the ovariectomized groups and the non-ovariectomized groups. Monthly food consumption (MFC) showed significant decreases (p <0.05) in Groups OVX, OVX-72, and OVX-100, as monthly ponderal variation (MPV) showed significant differences (p <0.005), particularly Group OVX-72 vs. Group OVX. However, none of the PEMFs used produced an amelioration of castration-induced osteopenia by changing the balance between bone resorption and formation. As opposed to PEMFs at 50 and 100 Hz, the effect on bone of PEMFs at 72 Hz could have been hidden by systemic application of an instrument conceived for local therapy only.

UR - http://www.scopus.com/inward/record.url?scp=0033409463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033409463&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033409463

VL - 18

SP - 119

EP - 131

JO - Electro- and Magnetobiology

JF - Electro- and Magnetobiology

SN - 1061-9526

IS - 2

ER -