Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study

Michael R. Gold, Christophe Thébault, Cecilia Linde, William T. Abraham, Bart Gerritse, Stefano Ghio, Martin St. John Sutton, Jean Claude Daubert

Research output: Contribution to journalArticlepeer-review

Abstract

Background-Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure. Methods and Results-Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial of CRT among 610 patients with mild heart failure. Baseline and CRT-paced QRS durations and baseline QRS morphology were evaluated by blinded core laboratories. The mean baseline QRS duration was 151±23 milliseconds, and 60.5% of subjects had left bundle-branch block (LBBB). Patients with LBBB experienced a 25.3-mL/m mean reduction in left ventricular end-systolic volume index (P

Original languageEnglish
Pages (from-to)822-829
Number of pages8
JournalCirculation
Volume126
Issue number7
DOIs
Publication statusPublished - Aug 14 2012

Keywords

  • bundle-branch block
  • cardiomyopathy
  • heart failure
  • pacing

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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