Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study

Michael R. Gold; Christophe Thébault; Cecilia Linde; William T. Abraham; Bart Gerritse; Stefano Ghio; Martin St. John Sutton; Jean Claude Daubert

doi:10.1161/CIRCULATIONAHA.112.097709

Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study

Michael R. Gold, Christophe Thébault, Cecilia Linde, William T. Abraham, Bart Gerritse, Stefano Ghio, Martin St. John Sutton, Jean Claude Daubert

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Background-Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure. Methods and Results-Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial of CRT among 610 patients with mild heart failure. Baseline and CRT-paced QRS durations and baseline QRS morphology were evaluated by blinded core laboratories. The mean baseline QRS duration was 151±23 milliseconds, and 60.5% of subjects had left bundle-branch block (LBBB). Patients with LBBB experienced a 25.3-mL/m mean reduction in left ventricular end-systolic volume index (P

Original language	English
Pages (from-to)	822-829
Number of pages	8
Journal	Circulation
Volume	126
Issue number	7
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.112.097709
Publication status	Published - Aug 14 2012

Keywords

bundle-branch block
cardiomyopathy
heart failure
pacing

ASJC Scopus subject areas

Physiology (medical)
Cardiology and Cardiovascular Medicine

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Gold, M. R., Thébault, C., Linde, C., Abraham, W. T., Gerritse, B., Ghio, S., St. John Sutton, M., & Daubert, J. C. (2012). Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study. Circulation, 126(7), 822-829. https://doi.org/10.1161/CIRCULATIONAHA.112.097709

Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure : Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study. / Gold, Michael R.; Thébault, Christophe; Linde, Cecilia; Abraham, William T.; Gerritse, Bart; Ghio, Stefano; St. John Sutton, Martin; Daubert, Jean Claude.

In: Circulation, Vol. 126, No. 7, 14.08.2012, p. 822-829.

Research output: Contribution to journal › Article › peer-review

Gold, MR, Thébault, C, Linde, C, Abraham, WT, Gerritse, B, Ghio, S, St. John Sutton, M & Daubert, JC 2012, 'Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study', Circulation, vol. 126, no. 7, pp. 822-829. https://doi.org/10.1161/CIRCULATIONAHA.112.097709

Gold MR, Thébault C, Linde C, Abraham WT, Gerritse B, Ghio S et al. Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study. Circulation. 2012 Aug 14;126(7):822-829. https://doi.org/10.1161/CIRCULATIONAHA.112.097709

Gold, Michael R. ; Thébault, Christophe ; Linde, Cecilia ; Abraham, William T. ; Gerritse, Bart ; Ghio, Stefano ; St. John Sutton, Martin ; Daubert, Jean Claude. / Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure : Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study. In: Circulation. 2012 ; Vol. 126, No. 7. pp. 822-829.

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