TY - JOUR
T1 - Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure
T2 - Results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study
AU - Gold, Michael R.
AU - Thébault, Christophe
AU - Linde, Cecilia
AU - Abraham, William T.
AU - Gerritse, Bart
AU - Ghio, Stefano
AU - St. John Sutton, Martin
AU - Daubert, Jean Claude
PY - 2012/8/14
Y1 - 2012/8/14
N2 - Background-Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure. Methods and Results-Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial of CRT among 610 patients with mild heart failure. Baseline and CRT-paced QRS durations and baseline QRS morphology were evaluated by blinded core laboratories. The mean baseline QRS duration was 151±23 milliseconds, and 60.5% of subjects had left bundle-branch block (LBBB). Patients with LBBB experienced a 25.3-mL/m mean reduction in left ventricular end-systolic volume index (P
AB - Background-Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure. Methods and Results-Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial of CRT among 610 patients with mild heart failure. Baseline and CRT-paced QRS durations and baseline QRS morphology were evaluated by blinded core laboratories. The mean baseline QRS duration was 151±23 milliseconds, and 60.5% of subjects had left bundle-branch block (LBBB). Patients with LBBB experienced a 25.3-mL/m mean reduction in left ventricular end-systolic volume index (P
KW - bundle-branch block
KW - cardiomyopathy
KW - heart failure
KW - pacing
UR - http://www.scopus.com/inward/record.url?scp=84865220730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865220730&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.112.097709
DO - 10.1161/CIRCULATIONAHA.112.097709
M3 - Article
C2 - 22781424
AN - SCOPUS:84865220730
VL - 126
SP - 822
EP - 829
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 7
ER -