A study of the transcutaneous penetration of two nicotinates in white and Hispano-American skin is presented. Absorption of nicotinates was monitored using laser Doppler velocimetry (LDV), a non-invasive technique to study cutaneous blood flow. The induced erythema after the application of 10 mM methyl nicotinate and hexyl nicotinate was recorded for one hour. The chemicals were diluted in 60:40 water:isopropyl alcohol. To assess the influence of skin surface lipids and water content of the stratum corneum on penetration, the drugs were applied to the upper back on untreated skin and to skin sites pre-treated by occlusion or delipidisation. The initial response recorded at fifteen minutes (IR), the peak response (PR) and the area under the curve response (AUC) allowed characterisation of the pharmaco-dynamic response. Neither racial differences between whites and Hispano-Americans, nor differences in effects between the two nicotinates were detected. Pre-treatments elicited different peak LDV responses (p <0.05). The data are discussed in the light of racial differences observed between whites and blacks.
|Number of pages||8|
|Journal||Bioengineering and the Skin|
|Publication status||Published - 1988|
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