Effect of race on percutaneous penetration of nicotinates in human skin

A comparison of whites and Hispano-Americans

E. Berardesca, H. I. Maibach

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A study of the transcutaneous penetration of two nicotinates in white and Hispano-American skin is presented. Absorption of nicotinates was monitored using laser Doppler velocimetry (LDV), a non-invasive technique to study cutaneous blood flow. The induced erythema after the application of 10 mM methyl nicotinate and hexyl nicotinate was recorded for one hour. The chemicals were diluted in 60:40 water:isopropyl alcohol. To assess the influence of skin surface lipids and water content of the stratum corneum on penetration, the drugs were applied to the upper back on untreated skin and to skin sites pre-treated by occlusion or delipidisation. The initial response recorded at fifteen minutes (IR), the peak response (PR) and the area under the curve response (AUC) allowed characterisation of the pharmaco-dynamic response. Neither racial differences between whites and Hispano-Americans, nor differences in effects between the two nicotinates were detected. Pre-treatments elicited different peak LDV responses (p <0.05). The data are discussed in the light of racial differences observed between whites and blacks.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalBioengineering and the Skin
Volume4
Issue number1
Publication statusPublished - 1988

Fingerprint

Skin
Laser-Doppler Flowmetry
2-Propanol
Water
Erythema
Cornea
Area Under Curve
Lipids
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Biophysics
  • Dermatology

Cite this

Effect of race on percutaneous penetration of nicotinates in human skin : A comparison of whites and Hispano-Americans. / Berardesca, E.; Maibach, H. I.

In: Bioengineering and the Skin, Vol. 4, No. 1, 1988, p. 31-38.

Research output: Contribution to journalArticle

@article{7cb673a1f80b4b4f95e03c8cc70124a1,
title = "Effect of race on percutaneous penetration of nicotinates in human skin: A comparison of whites and Hispano-Americans",
abstract = "A study of the transcutaneous penetration of two nicotinates in white and Hispano-American skin is presented. Absorption of nicotinates was monitored using laser Doppler velocimetry (LDV), a non-invasive technique to study cutaneous blood flow. The induced erythema after the application of 10 mM methyl nicotinate and hexyl nicotinate was recorded for one hour. The chemicals were diluted in 60:40 water:isopropyl alcohol. To assess the influence of skin surface lipids and water content of the stratum corneum on penetration, the drugs were applied to the upper back on untreated skin and to skin sites pre-treated by occlusion or delipidisation. The initial response recorded at fifteen minutes (IR), the peak response (PR) and the area under the curve response (AUC) allowed characterisation of the pharmaco-dynamic response. Neither racial differences between whites and Hispano-Americans, nor differences in effects between the two nicotinates were detected. Pre-treatments elicited different peak LDV responses (p <0.05). The data are discussed in the light of racial differences observed between whites and blacks.",
author = "E. Berardesca and Maibach, {H. I.}",
year = "1988",
language = "English",
volume = "4",
pages = "31--38",
journal = "Bioengineering and the Skin",
issn = "0266-3082",
publisher = "MTP Press",
number = "1",

}

TY - JOUR

T1 - Effect of race on percutaneous penetration of nicotinates in human skin

T2 - A comparison of whites and Hispano-Americans

AU - Berardesca, E.

AU - Maibach, H. I.

PY - 1988

Y1 - 1988

N2 - A study of the transcutaneous penetration of two nicotinates in white and Hispano-American skin is presented. Absorption of nicotinates was monitored using laser Doppler velocimetry (LDV), a non-invasive technique to study cutaneous blood flow. The induced erythema after the application of 10 mM methyl nicotinate and hexyl nicotinate was recorded for one hour. The chemicals were diluted in 60:40 water:isopropyl alcohol. To assess the influence of skin surface lipids and water content of the stratum corneum on penetration, the drugs were applied to the upper back on untreated skin and to skin sites pre-treated by occlusion or delipidisation. The initial response recorded at fifteen minutes (IR), the peak response (PR) and the area under the curve response (AUC) allowed characterisation of the pharmaco-dynamic response. Neither racial differences between whites and Hispano-Americans, nor differences in effects between the two nicotinates were detected. Pre-treatments elicited different peak LDV responses (p <0.05). The data are discussed in the light of racial differences observed between whites and blacks.

AB - A study of the transcutaneous penetration of two nicotinates in white and Hispano-American skin is presented. Absorption of nicotinates was monitored using laser Doppler velocimetry (LDV), a non-invasive technique to study cutaneous blood flow. The induced erythema after the application of 10 mM methyl nicotinate and hexyl nicotinate was recorded for one hour. The chemicals were diluted in 60:40 water:isopropyl alcohol. To assess the influence of skin surface lipids and water content of the stratum corneum on penetration, the drugs were applied to the upper back on untreated skin and to skin sites pre-treated by occlusion or delipidisation. The initial response recorded at fifteen minutes (IR), the peak response (PR) and the area under the curve response (AUC) allowed characterisation of the pharmaco-dynamic response. Neither racial differences between whites and Hispano-Americans, nor differences in effects between the two nicotinates were detected. Pre-treatments elicited different peak LDV responses (p <0.05). The data are discussed in the light of racial differences observed between whites and blacks.

UR - http://www.scopus.com/inward/record.url?scp=0023759602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023759602&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 31

EP - 38

JO - Bioengineering and the Skin

JF - Bioengineering and the Skin

SN - 0266-3082

IS - 1

ER -