Effect of radioprotectors on damage induced by alkylating agents on tumoural and normal tissues

S. Garattini, V. Palma, I. R D Innocenti, A. Guaitani

Research output: Contribution to journalArticle

Abstract

A quantitative investigation was carried out to establish the usefulness of radioprotector drugs in combination with alkylating agents for the chemotherapy of Ehrlich carcinoma and Sarcoma 180 in mice. Tumoural growth, spleen weight and number of blood white cells were measured. The results show that a protection against the damage induced by alkylating agents on spleen and white cells was always achieved at doses of radioprotectors able to prevent also the antitumoural activity of the same alkylating agent. Despite the large range of doses and schedule of treatment tried it was impossible to produce evidence that the combination radioprotectors + alkylating agents was useful.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalEuropean Journal of Cancer (1965)
Volume2
Issue number3
Publication statusPublished - Aug 1966

ASJC Scopus subject areas

  • Medicine(all)

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