Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials

S. Darby, P. McGale, C. Correa, C. Taylor, R. Arriagada, M. Clarke, D. Cutter, C. Davies, M. Ewertz, J. Godwin, R. Gray, L. Pierce, T. Whelan, Y. Wang, R. Peto, K. Albain, S. Anderson, R. Arriagada, W. Barlow, J. BerghJ. Bliss, M. Buyse, D. Cameron, E. Carrasco, M. Clarke, C. Correa, A. Coates, R. Collins, J. Costantino, D. Cutter, J. Cuzick, S. Darby, N. Davidson, C. Davies, K. Davies, A. Delmestri, A. Di Leo, M. Dowsett, P. Elphinstone, V. Evans, M. Ewertz, R. Gelber, L. Gettins, C. Geyer, A. Goldhirsch, J. Godwin, R. Gray, C. Gregory, D. Hayes, C. Hill, J. Ingle, R. Jakesz, S. James, M. Kaufmann, A. Kerr, E. MacKinnon, P. McGale, T. McHugh, L. Norton, Y. Ohashi, S. Paik, H. C. Pan, E. Perez, R. Peto, M. Piccart, L. Pierce, K. Pritchard, G. Pruneri, V. Raina, P. Ravdin, J. Robertson, E. Rutgers, Y. F Shao, S. Swain, C. Taylor, P. Valagussa, G. Viale, T. Whelan, E. Winer, Y. Wang, W. Wood

Research output: Contribution to journalArticle

Abstract

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. We undertook a meta-analysis of individual patient data for 10 801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0 to 19·3 (absolute reduction 15·7, 95 CI 13·7-17·7, 2p

Original languageEnglish
Pages (from-to)1707-1716
Number of pages10
JournalLancet
Volume378
Issue number9804
DOIs
Publication statusPublished - Nov 12 2011

ASJC Scopus subject areas

  • Medicine(all)

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    Darby, S., McGale, P., Correa, C., Taylor, C., Arriagada, R., Clarke, M., Cutter, D., Davies, C., Ewertz, M., Godwin, J., Gray, R., Pierce, L., Whelan, T., Wang, Y., Peto, R., Albain, K., Anderson, S., Arriagada, R., Barlow, W., ... Wood, W. (2011). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet, 378(9804), 1707-1716. https://doi.org/10.1016/S0140-6736(11)61629-2