Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: Meta-analysis of individual patient data for 8135 women in 22 randomised trials

P. McGale, C. Taylor, C. Correa, D. Cutter, F. Duane, M. Ewertz, R. Gray, G. Mannu, R. Peto, T. Whelan, Y. Wang, Z. Wang, S. Darby, K. Albain, S. Anderson, R. Arriagada, W. Barlow, J. Bergh, E. Bergsten Nordström, J. BlissJ. A. Burrett, M. Buyse, D. Cameron, E. Carrasco, M. Clarke, R. Coleman, C. Correa, A. Coates, R. Collins, J. Costantino, D. Cutter, J. Cuzick, S. Darby, N. Davidson, C. Davies, K. Davies, A. Delmestri, A. Di Leo, M. Dowsett, P. Elphinstone, V. Evans, M. Ewertz, J. Forbes, R. Gelber, L. Gettins, C. Geyer, L. Gianni, M. Gnant, A. Goldhirsch, J. Godwin, R. Gray, C. Gregory, D. Hayes, C. Hill, J. Ingle, R. Jakesz, S. James, W. Janni, M. Kaufmann, A. Kerr, H. Liu, E. MacKinnon, M. Martín, P. McGale, T. McHugh, P. Morris, L. Norton, Y. Ohashi, S. Paik, H. C. Pan, E. Perez, R. Peto, M. Piccart, L. Pierce, K. Pritchard, G. Pruneri, V. Raina, P. Ravdin, J. Robertson, E. Rutgers, Y. F. Shao, J. Sparano, S. Swain, C. Taylor, P. Valagussa, G. Viale, G. Von Minckwitz, T. Whelan, E. Winer, X. Wiang, Y. Wang, W. Wood

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Abstract

Background Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection. Methods We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22 trials of radiotherapy to the chest wall and regional lymph nodes after mastectomy and axillary surgery versus the same surgery but no radiotherapy. Follow-up lasted 10 years for recurrence and to Jan 1, 2009, for mortality. Analyses were stratified by trial, individual follow-up year, age at entry, and pathological nodal status. Findings 3786 women had axillary dissection to at least level II and had zero, one to three, or four or more positive nodes. All were in trials in which radiotherapy included the chest wall, supraclavicular or axillary fossa (or both), and internal mammary chain. For 700 women with axillary dissection and no positive nodes, radiotherapy had no significant effect on locoregional recurrence (two-sided significance level [2p]>0·1), overall recurrence (rate ratio [RR], irradiated vs not, 1·06, 95% CI 0·76-1·48, 2p>0·1), or breast cancer mortality (RR 1·18, 95% CI 0·89-1·55, 2p>0·1). For 1314 women with axillary dissection and one to three positive nodes, radiotherapy reduced locoregional recurrence (2p

Original languageEnglish
Pages (from-to)2127-2135
Number of pages9
JournalLancet
Volume383
Issue number9935
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Medicine(all)

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McGale, P., Taylor, C., Correa, C., Cutter, D., Duane, F., Ewertz, M., Gray, R., Mannu, G., Peto, R., Whelan, T., Wang, Y., Wang, Z., Darby, S., Albain, K., Anderson, S., Arriagada, R., Barlow, W., Bergh, J., Bergsten Nordström, E., ... Wood, W. (2014). Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: Meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet, 383(9935), 2127-2135. https://doi.org/10.1016/S0140-6736(14)60488-8