Effect of ranolazine on arterial endothelial function in patients with type 2 diabetes mellitus

Priscilla Lamendola, Roberto Nerla, Dario Pitocco, Angelo Villano, Giuseppe Scavone, Alessandra Stazi, Giulio Russo, Antonino Di Franco, Alfonso Sestito, Giovanni Ghirlanda, Gaetano A. Lanza, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Objective: To assess the effect of ranolazine on systemic vascular function in patients with type II diabetes mellitus (T2DM). Methods: We randomized 30 consecutive T2DM patients with no evidence of cardiovascular disease and no insulin therapy to receive one of the following 3 forms of treatment in a blinded fashion: ranolazine, 375 mg bid for 3 weeks (group 1); ranolazine, 375 mg bid for 2 weeks, followed by placebo bid for 1 week (group 2); placebo bid for 3 weeks (group 3). Flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) of the right brachial artery were assessed at baseline and after 48 h, and 2 and 3 weeks. Results: FMD and NMD were similar among groups at baseline. Compared to the basal value, FMD significantly improved after 2 weeks in group 1 and in group 2 (p <0.01 for both), but not in group 3. At 3 weeks, FMD remained improved, compared to baseline, in group 1 (p <0.05), whereas returned to basal values in group 2 (p = 0.89 vs. baseline). No changes in NMD were observed in any group. Conclusions: In this controlled study, ranolazine was able to improve endothelial function in T2DM patients.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalAtherosclerosis
Volume226
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Endothelial function
  • Ranolazine
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Lamendola, P., Nerla, R., Pitocco, D., Villano, A., Scavone, G., Stazi, A., Russo, G., Di Franco, A., Sestito, A., Ghirlanda, G., Lanza, G. A., & Crea, F. (2013). Effect of ranolazine on arterial endothelial function in patients with type 2 diabetes mellitus. Atherosclerosis, 226(1), 157-160. https://doi.org/10.1016/j.atherosclerosis.2012.10.051