EFFICACIA DEL GH-RELEASING HORMONE E DEL GH-BIOSINTETICO IN UN GRUPPO DI BAMBINI CON DEFICIT DI ORMONE DELLA CRESCITA

Translated title of the contribution: Effect of recombinant growth hormone (rGH) and of growth hormone-releasing hormone (GHRH) in growth hormone-deficient children

I. Biscaldi, A. Fiori, A. Moretta, A. Valtorta

Research output: Contribution to journalArticlepeer-review

Abstract

Eight GH-deficient children were treated with GHRH (1-44), once daily s.c. for 6-18 months. At the 6th month of therapy, 3 patients showed a catch-up growth ('responders'), while the remaining 5 did not ('non-responders'). In all patients treatment was discontinued after 6-18 months, when its effect on growth rate failed. After a wash out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating.

Translated title of the contributionEffect of recombinant growth hormone (rGH) and of growth hormone-releasing hormone (GHRH) in growth hormone-deficient children
Original languageItalian
Pages (from-to)145-146
Number of pages2
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Effect of recombinant growth hormone (rGH) and of growth hormone-releasing hormone (GHRH) in growth hormone-deficient children'. Together they form a unique fingerprint.

Cite this