EFFICACIA DEL GH-RELEASING HORMONE E DEL GH-BIOSINTETICO IN UN GRUPPO DI BAMBINI CON DEFICIT DI ORMONE DELLA CRESCITA

Translated title of the contribution: Effect of recombinant growth hormone (rGH) and of growth hormone-releasing hormone (GHRH) in growth hormone-deficient children

I. Biscaldi, A. Fiori, A. Moretta, A. Valtorta

Research output: Contribution to journalArticle

Abstract

Eight GH-deficient children were treated with GHRH (1-44), once daily s.c. for 6-18 months. At the 6th month of therapy, 3 patients showed a catch-up growth ('responders'), while the remaining 5 did not ('non-responders'). In all patients treatment was discontinued after 6-18 months, when its effect on growth rate failed. After a wash out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating.

Original languageItalian
Pages (from-to)145-146
Number of pages2
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number2
Publication statusPublished - 1990

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Growth Hormone-Releasing Hormone
Growth Hormone
Therapeutics
Growth

ASJC Scopus subject areas

  • Medicine(all)

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EFFICACIA DEL GH-RELEASING HORMONE E DEL GH-BIOSINTETICO IN UN GRUPPO DI BAMBINI CON DEFICIT DI ORMONE DELLA CRESCITA. / Biscaldi, I.; Fiori, A.; Moretta, A.; Valtorta, A.

In: Medicina - Rivista della Enciclopedia Medica Italiana, Vol. 10, No. 2, 1990, p. 145-146.

Research output: Contribution to journalArticle

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abstract = "Eight GH-deficient children were treated with GHRH (1-44), once daily s.c. for 6-18 months. At the 6th month of therapy, 3 patients showed a catch-up growth ('responders'), while the remaining 5 did not ('non-responders'). In all patients treatment was discontinued after 6-18 months, when its effect on growth rate failed. After a wash out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating.",
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