Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice

Maria Luisa Balestrieri; Carmela Fiorito; Ettore Crimi; Francesca Felice; Concetta Schiano; Lara Milone; Amelia Casamassimi; Alfonso Giovane; Vincenzo Grimaldi; Vincenzo del Giudice; Pellegrino Biagio Minucci; Francesco Paolo Mancini; Luigi Servillo; Francesco Paolo D'Armiento; Bartolomeo Farzati; Claudio Napoli

doi:10.1016/j.ijcard.2007.11.081

Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice

Maria Luisa Balestrieri, Carmela Fiorito, Ettore Crimi, Francesca Felice, Concetta Schiano, Lara Milone, Amelia Casamassimi, Alfonso Giovane, Vincenzo Grimaldi, Vincenzo del Giudice, Pellegrino Biagio Minucci, Francesco Paolo Mancini, Luigi Servillo, Francesco Paolo D'Armiento, Bartolomeo Farzati, Claudio Napoli

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P <0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P <0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.

Original language	English
Pages (from-to)	295-297
Number of pages	3
Journal	International Journal of Cardiology
Volume	126
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2007.11.081
Publication status	Published - May 23 2008

Keywords

Antioxidants
Endothelial progenitor cells
Physical exercise
Red wine

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2007.11.081

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Balestrieri, M. L., Fiorito, C., Crimi, E., Felice, F., Schiano, C., Milone, L., Casamassimi, A., Giovane, A., Grimaldi, V., del Giudice, V., Minucci, P. B., Mancini, F. P., Servillo, L., D'Armiento, F. P., Farzati, B., & Napoli, C. (2008). Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice. International Journal of Cardiology, 126(2), 295-297. https://doi.org/10.1016/j.ijcard.2007.11.081

Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice. / Balestrieri, Maria Luisa; Fiorito, Carmela; Crimi, Ettore; Felice, Francesca; Schiano, Concetta; Milone, Lara; Casamassimi, Amelia; Giovane, Alfonso; Grimaldi, Vincenzo; del Giudice, Vincenzo; Minucci, Pellegrino Biagio; Mancini, Francesco Paolo; Servillo, Luigi; D'Armiento, Francesco Paolo; Farzati, Bartolomeo; Napoli, Claudio.

In: International Journal of Cardiology, Vol. 126, No. 2, 23.05.2008, p. 295-297.

Research output: Contribution to journal › Article › peer-review

Balestrieri, ML, Fiorito, C, Crimi, E, Felice, F, Schiano, C, Milone, L, Casamassimi, A, Giovane, A, Grimaldi, V, del Giudice, V, Minucci, PB, Mancini, FP, Servillo, L, D'Armiento, FP, Farzati, B & Napoli, C 2008, 'Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice', International Journal of Cardiology, vol. 126, no. 2, pp. 295-297. https://doi.org/10.1016/j.ijcard.2007.11.081

Balestrieri, Maria Luisa ; Fiorito, Carmela ; Crimi, Ettore ; Felice, Francesca ; Schiano, Concetta ; Milone, Lara ; Casamassimi, Amelia ; Giovane, Alfonso ; Grimaldi, Vincenzo ; del Giudice, Vincenzo ; Minucci, Pellegrino Biagio ; Mancini, Francesco Paolo ; Servillo, Luigi ; D'Armiento, Francesco Paolo ; Farzati, Bartolomeo ; Napoli, Claudio. / Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice. In: International Journal of Cardiology. 2008 ; Vol. 126, No. 2. pp. 295-297.

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abstract = "Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P <0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P <0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.",

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AU - Casamassimi, Amelia

AU - Giovane, Alfonso

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AU - del Giudice, Vincenzo

AU - Minucci, Pellegrino Biagio

AU - Mancini, Francesco Paolo

AU - Servillo, Luigi

AU - D'Armiento, Francesco Paolo

AU - Farzati, Bartolomeo

AU - Napoli, Claudio

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Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice

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Keywords

ASJC Scopus subject areas

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