Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients

Roberta Zanardini; Anna Gazzoli; Mariacarla Ventriglia; Jorge Perez; Stefano Bignotti; Paolo Maria Rossini; Massimo Gennarelli; Luisella Bocchio-Chiavetto

doi:10.1016/j.jad.2005.12.029

Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients

Roberta Zanardini, Anna Gazzoli, Mariacarla Ventriglia, Jorge Perez, Stefano Bignotti, Paolo Maria Rossini, Massimo Gennarelli, Luisella Bocchio-Chiavetto

Research output: Contribution to journal › Article

Abstract

Background: Depression has been associated with low brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs appear to mend this alteration. The purpose of this study was to assess BDNF serum levels in drug resistant depressed patients before and after repetitive Transcranial Magnetic Stimulation (rTMS) antidepressant treatment. Methods: BDNF levels were measured in serum of 16 resistant depressed patients using the ELISA technique. Results: BDNF baseline levels showed a negative correlation with illness severity measured by HDRS scores (R = - 0.517, p = 0.04) and a significant increase of serum BDNF was found after rTMS treatment (t = - 2.549, df = 15, p = 0.022). Conclusions: Our findings support the relationship between decreased serum BDNF and depression symptomatology and suggest a normalizing effect of rTMS antidepressant treatment. Further replications in larger samples will help to clarify the relevance of this preliminary data in the rTMS mechanism of action.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Journal of Affective Disorders
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/j.jad.2005.12.029
Publication status	Published - Mar 2006

Keywords

BDNF
Depression
Drug-resistant
HDRS
rTMS
Serum

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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Zanardini, R., Gazzoli, A., Ventriglia, M., Perez, J., Bignotti, S., Maria Rossini, P., Gennarelli, M., & Bocchio-Chiavetto, L. (2006). Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. Journal of Affective Disorders, 91(1), 83-86. https://doi.org/10.1016/j.jad.2005.12.029

Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. / Zanardini, Roberta; Gazzoli, Anna; Ventriglia, Mariacarla; Perez, Jorge; Bignotti, Stefano; Maria Rossini, Paolo ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella.

In: Journal of Affective Disorders, Vol. 91, No. 1, 03.2006, p. 83-86.

Research output: Contribution to journal › Article

Zanardini, Roberta ; Gazzoli, Anna ; Ventriglia, Mariacarla ; Perez, Jorge ; Bignotti, Stefano ; Maria Rossini, Paolo ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella. / Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. In: Journal of Affective Disorders. 2006 ; Vol. 91, No. 1. pp. 83-86.

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