Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients

Roberta Zanardini, Anna Gazzoli, Mariacarla Ventriglia, Jorge Perez, Stefano Bignotti, Paolo Maria Rossini, Massimo Gennarelli, Luisella Bocchio-Chiavetto

Research output: Contribution to journalArticle

Abstract

Background: Depression has been associated with low brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs appear to mend this alteration. The purpose of this study was to assess BDNF serum levels in drug resistant depressed patients before and after repetitive Transcranial Magnetic Stimulation (rTMS) antidepressant treatment. Methods: BDNF levels were measured in serum of 16 resistant depressed patients using the ELISA technique. Results: BDNF baseline levels showed a negative correlation with illness severity measured by HDRS scores (R = - 0.517, p = 0.04) and a significant increase of serum BDNF was found after rTMS treatment (t = - 2.549, df = 15, p = 0.022). Conclusions: Our findings support the relationship between decreased serum BDNF and depression symptomatology and suggest a normalizing effect of rTMS antidepressant treatment. Further replications in larger samples will help to clarify the relevance of this preliminary data in the rTMS mechanism of action.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalJournal of Affective Disorders
Volume91
Issue number1
DOIs
Publication statusPublished - Mar 2006

Keywords

  • BDNF
  • Depression
  • Drug-resistant
  • HDRS
  • rTMS
  • Serum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Fingerprint Dive into the research topics of 'Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients'. Together they form a unique fingerprint.

  • Cite this