Effect of resection and outcome in patients with retroperitoneal sarcoma

Antonio Chiappa, Andrew P. Zbar, Roberto Biffi, Emilio Bertani, Francesca Biella, Giuseppe Viale, Ugo Pace, Giancarlo Pruneri, Roberto Orecchia, Roberta Lazzari, Davide Poldi, Bruno Andreoni

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Background: A consecutive series of 47 patients with retroperitoneal sarcoma (RPS) were resected and prospectively followed. Method: Between July 1994 and March 2005, 47 patients (24 men, 23 women; mean age, 56 years; range, 17-82 years) were evaluated. Results: A total of 23 patients had primary RPS and 24 patients had recurrent RPS. A total of 30 out of 47 patients (64%) underwent removal of contiguous intra-abdominal organs. The peroperative mortality was nil and significant preoperative complications occurred in eight cases only (17%). High tumour grade and incomplete resection were significant variables for a worse survival in all 47 patients, both in the univariate and multivariate analyses (P = 0.008 and P = 0.016, respectively). Among 28 radically resected patients, only histological grade affected overall survival (90% 5-year survival for low-grade tumour vs 26% 5-year survival for high-grade tumour; P = 0.006) with a similar effect noted for disease-free survival. Conclusions: Histological grade was the only factor that affected overall and disease-free survival for RPS tumours. An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalANZ Journal of Surgery
Issue number6
Publication statusPublished - Jun 2006


  • Chemotherapy
  • Radiotherapy
  • Retroperitoneal sarcoma
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Surgery


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