Effect of reserpine on adenylate cyclase system of rat striatum

K. Kumakura, A. Carenzi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

We have investigated the properties of dopamine-dependent adenylate cyclase in rat striatal homogenates, 20 h after reserpine treatment. In this experimental condition, we have found that the affinity of the enzyme for dopamine is greatly enhanced. On the other hand, the concentration of apomorphine required to produced half-maximal activation of the enzyme in striatal homogenates of controls and reserpine-treated rats is not changed. The unchanged affinity of adenylate cyclase for the substrate (ATP:Mg++) indicates that reserpine probably affects the receptor component of the enzyme.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalNeurochemical Research
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1976

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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    Kumakura, K., Carenzi, A., Spano, P. F., & Trabucchi, M. (1976). Effect of reserpine on adenylate cyclase system of rat striatum. Neurochemical Research, 1(3), 329-336. https://doi.org/10.1007/BF00973777