Effect of SC-45355 on cholesterol biosynthesis in incubated human blood mononuclear cells

F. Blasi, R. Cosentini, M. Trinchera, D. Sommariva, A. Fasoli

Research output: Contribution to journalArticle

Abstract

SC-45355 (3-(12-carboxy-12-methyl)tridecyl-3-hydroxypentanedioic acid), a new analogue of 3-hydroxy-3-methylglutaric acid (HMG), has been found to inhibit the incorporation of labeled sodium acetate and labeled HMG-coenzyme A into non-saponifiable lipids, mainly cholesterol, in incubated blood mononuclear cells from normal subjects. The presence of SC-45355 in the incubation medium did not affect the incorporation of labeled mevalonate into sterols. This strongly suggests that the drug reduces cholesterol biosynthesis in incubated blood mononuclear cells by inhibiting HMG-coenzyme A reductase.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalCurrent Therapeutic Research
Volume47
Issue number1
Publication statusPublished - 1990

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Coenzyme A
Meglutol
Blood Cells
Cholesterol
Sodium Acetate
Mevalonic Acid
Sterols
Oxidoreductases
Lipids
Acids
Pharmaceutical Preparations
3-methylglutaric acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blasi, F., Cosentini, R., Trinchera, M., Sommariva, D., & Fasoli, A. (1990). Effect of SC-45355 on cholesterol biosynthesis in incubated human blood mononuclear cells. Current Therapeutic Research, 47(1), 67-75.

Effect of SC-45355 on cholesterol biosynthesis in incubated human blood mononuclear cells. / Blasi, F.; Cosentini, R.; Trinchera, M.; Sommariva, D.; Fasoli, A.

In: Current Therapeutic Research, Vol. 47, No. 1, 1990, p. 67-75.

Research output: Contribution to journalArticle

Blasi, F, Cosentini, R, Trinchera, M, Sommariva, D & Fasoli, A 1990, 'Effect of SC-45355 on cholesterol biosynthesis in incubated human blood mononuclear cells', Current Therapeutic Research, vol. 47, no. 1, pp. 67-75.
Blasi, F. ; Cosentini, R. ; Trinchera, M. ; Sommariva, D. ; Fasoli, A. / Effect of SC-45355 on cholesterol biosynthesis in incubated human blood mononuclear cells. In: Current Therapeutic Research. 1990 ; Vol. 47, No. 1. pp. 67-75.
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