Effect of serotonin on plasma aldosterone in man

Franco Mantero; G. Opocher; M. Boscaro; D. Armanini

doi:10.1007/BF03350498

Effect of serotonin on plasma aldosterone in man

Franco Mantero, G. Opocher, M. Boscaro, D. Armanini

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Serotonin (5HT) is known to be one of the most active aldosterone-stimulating substances in rat adrenal tissue, but its effect in vivo has been scarcely investigated, especially in man. We have studied the effect of an infusion of 5HT in 14 normal subjects. Plasma aldosterone significantly increased during 5HT infusion, while Cortisol and plasma renin activity were not modified. No changes in serum K, blood pressure or heart rate were noticed. These data suggest that 5HT may influence aldosterone secretion also in man.

Original language	English
Pages (from-to)	97-99
Number of pages	3
Journal	Journal of Endocrinological Investigation
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/BF03350498
Publication status	Published - 1982

Keywords

aldosterone
Serotonin

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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AU - Armanini, D.

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AB - Serotonin (5HT) is known to be one of the most active aldosterone-stimulating substances in rat adrenal tissue, but its effect in vivo has been scarcely investigated, especially in man. We have studied the effect of an infusion of 5HT in 14 normal subjects. Plasma aldosterone significantly increased during 5HT infusion, while Cortisol and plasma renin activity were not modified. No changes in serum K, blood pressure or heart rate were noticed. These data suggest that 5HT may influence aldosterone secretion also in man.

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