Effect of serotonin on plasma aldosterone in man

Franco Mantero, G. Opocher, M. Boscaro, D. Armanini

Research output: Contribution to journalArticlepeer-review


Serotonin (5HT) is known to be one of the most active aldosterone-stimulating substances in rat adrenal tissue, but its effect in vivo has been scarcely investigated, especially in man. We have studied the effect of an infusion of 5HT in 14 normal subjects. Plasma aldosterone significantly increased during 5HT infusion, while Cortisol and plasma renin activity were not modified. No changes in serum K, blood pressure or heart rate were noticed. These data suggest that 5HT may influence aldosterone secretion also in man.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - 1982


  • aldosterone
  • Serotonin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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