Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement: Results from a propensity-matched population of the Italian OBSERVANT multicenter study

Francesco Onorati, Paola D'Errigo, Claudio Grossi, Marco Barbanti, Marco Ranucci, Daniel Remo Covello, Stefano Rosato, Alice Maraschini, Gennaro Santoro, Corrado Tamburino, Fulvia Seccareccia, Francesco Santini, Lorenzo Menicanti

Research output: Contribution to journalArticle

Abstract

Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P

Original languageEnglish
Pages (from-to)568-575
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume147
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Left Ventricular Dysfunction
Aortic Valve
Surgical Instruments
Multicenter Studies
Population
Mortality
National Institutes of Health (U.S.)
Comorbidity
Heart Diseases
Creatinine
Stroke
Myocardial Infarction
Morbidity
Kidney
Transcatheter Aortic Valve Replacement
Incidence
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement : Results from a propensity-matched population of the Italian OBSERVANT multicenter study. / Onorati, Francesco; D'Errigo, Paola; Grossi, Claudio; Barbanti, Marco; Ranucci, Marco; Covello, Daniel Remo; Rosato, Stefano; Maraschini, Alice; Santoro, Gennaro; Tamburino, Corrado; Seccareccia, Fulvia; Santini, Francesco; Menicanti, Lorenzo.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 147, No. 2, 02.2014, p. 568-575.

Research output: Contribution to journalArticle

Onorati, Francesco ; D'Errigo, Paola ; Grossi, Claudio ; Barbanti, Marco ; Ranucci, Marco ; Covello, Daniel Remo ; Rosato, Stefano ; Maraschini, Alice ; Santoro, Gennaro ; Tamburino, Corrado ; Seccareccia, Fulvia ; Santini, Francesco ; Menicanti, Lorenzo. / Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement : Results from a propensity-matched population of the Italian OBSERVANT multicenter study. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 147, No. 2. pp. 568-575.
@article{ac3845a25c224db9a05c2830fd8a6742,
title = "Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement: Results from a propensity-matched population of the Italian OBSERVANT multicenter study",
abstract = "Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35{\%}) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P",
author = "Francesco Onorati and Paola D'Errigo and Claudio Grossi and Marco Barbanti and Marco Ranucci and Covello, {Daniel Remo} and Stefano Rosato and Alice Maraschini and Gennaro Santoro and Corrado Tamburino and Fulvia Seccareccia and Francesco Santini and Lorenzo Menicanti",
year = "2014",
month = "2",
doi = "10.1016/j.jtcvs.2013.10.006",
language = "English",
volume = "147",
pages = "568--575",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement

T2 - Results from a propensity-matched population of the Italian OBSERVANT multicenter study

AU - Onorati, Francesco

AU - D'Errigo, Paola

AU - Grossi, Claudio

AU - Barbanti, Marco

AU - Ranucci, Marco

AU - Covello, Daniel Remo

AU - Rosato, Stefano

AU - Maraschini, Alice

AU - Santoro, Gennaro

AU - Tamburino, Corrado

AU - Seccareccia, Fulvia

AU - Santini, Francesco

AU - Menicanti, Lorenzo

PY - 2014/2

Y1 - 2014/2

N2 - Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P

AB - Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P

UR - http://www.scopus.com/inward/record.url?scp=84892373886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892373886&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2013.10.006

DO - 10.1016/j.jtcvs.2013.10.006

M3 - Article

C2 - 24263007

AN - SCOPUS:84892373886

VL - 147

SP - 568

EP - 575

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 2

ER -