Abstract
Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P
| Original language | English |
|---|---|
| Pages (from-to) | 568-575 |
| Number of pages | 8 |
| Journal | Journal of Thoracic and Cardiovascular Surgery |
| Volume | 147 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
- Pulmonary and Respiratory Medicine
Cite this
Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement : Results from a propensity-matched population of the Italian OBSERVANT multicenter study. / Onorati, Francesco; D'Errigo, Paola; Grossi, Claudio; Barbanti, Marco; Ranucci, Marco; Covello, Daniel Remo; Rosato, Stefano; Maraschini, Alice; Santoro, Gennaro; Tamburino, Corrado; Seccareccia, Fulvia; Santini, Francesco; Menicanti, Lorenzo.
In: Journal of Thoracic and Cardiovascular Surgery, Vol. 147, No. 2, 02.2014, p. 568-575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of severe left ventricular systolic dysfunction on hospital outcome after transcatheter aortic valve implantation or surgical aortic valve replacement
T2 - Results from a propensity-matched population of the Italian OBSERVANT multicenter study
AU - Onorati, Francesco
AU - D'Errigo, Paola
AU - Grossi, Claudio
AU - Barbanti, Marco
AU - Ranucci, Marco
AU - Covello, Daniel Remo
AU - Rosato, Stefano
AU - Maraschini, Alice
AU - Santoro, Gennaro
AU - Tamburino, Corrado
AU - Seccareccia, Fulvia
AU - Santini, Francesco
AU - Menicanti, Lorenzo
PY - 2014/2
Y1 - 2014/2
N2 - Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P
AB - Objective Despite demonstration of the superior outcomes of transcatheter aortic valve implantation (TAVI) versus optimal medical therapy for severe left ventricular systolic dysfunction, studies comparing TAVI and surgical aortic valve replacement (AVR) in this high-risk group have been lacking. Methods We performed propensity matching for age, gender, baseline comorbidities, previous interventions, priority at hospital admission, frailty score, New York Heart Association class, EuroSCORE, and associated cardiac diseases. Next, the 30-day mortality and procedure-related morbidity of 162 patients (81 TAVI vs 81 AVR) with severe left ventricular systolic dysfunction (ejection fraction ≤ 35%) were analyzed at the Italian National Institute of Health. Results The 30-day mortality was comparable (P =.37) between the 2 groups. The incidence of periprocedural acute myocardial infarction (P =.55), low output state (P =.27), stroke (P =.36), and renal dysfunction (peak creatinine level, P =.57) was also similar between the 2 groups. TAVI resulted in significantly greater postprocedural permanent pacemaker implantation (P =.01) and AVR in more periprocedural transfusions (P
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UR - http://www.scopus.com/inward/citedby.url?scp=84892373886&partnerID=8YFLogxK
U2 - 10.1016/j.jtcvs.2013.10.006
DO - 10.1016/j.jtcvs.2013.10.006
M3 - Article
C2 - 24263007
AN - SCOPUS:84892373886
VL - 147
SP - 568
EP - 575
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 2
ER -