Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers

R. Patrizi, F. Leonardo, F. Pelliccia, S. L. Chierchia, P. Galetta, E. Cerquetani, F. Frascà, F. Massimo, G. M C Rosano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. It has been suggested that phosphodiesterase 5 (PDE5) inhibition is potentially hazardous and that it increases the risk of cardiac events in patients with coronary artery disease. This study sought to evaluate whether PDE5 inhibition with sildenafil exerts any effect on exercise-induced myocardial ischemia in patients on beta-blockers. Methods. Fourteen patients underwent a baseline exercise test off-therapy and were then started on atenolol (100 mg once daily). After a run-in phase of 1 week, patients underwent a second exercise test and were randomized to receive either sildenafil (50 mg) or placebo given in a random order on two different occasions, 2 days apart. Exercise test was repeated 2 hours after the administration of sildenafil or placebo. Results. All patients had a > 1 mm ST-segment depression while off-therapy. Eight patients had a negative exercise test response after atenolol, which was unaltered by the adjunct of either sildenafil or placebo. In the remaining subjects, atenolol significantly prolonged the time to 1 mm ST-segment depression and the exercise time. Sildenafil and placebo did not reverse the beneficial effect of atenolol upon exercise-induced myocardial ischemia. Conclusions. PDE5 inhibition does not worsen exercise capacity and exercise-induced myocardial ischemia in patients with chronic stable angina whose symptoms and exercise test response are well controlled by beta-blocker therapy.

Original languageEnglish
Pages (from-to)841-844
Number of pages4
JournalItalian Heart Journal
Volume2
Issue number11
Publication statusPublished - 2001

Fingerprint

Stable Angina
Myocardial Ischemia
Exercise Test
Atenolol
Type 5 Cyclic Nucleotide Phosphodiesterases
Exercise
Placebos
Therapeutics
Exercise Therapy
Sildenafil Citrate
Coronary Artery Disease

Keywords

  • Exercise testing
  • Myocardial ischemia
  • Phosphodiesterase 5 inhibition
  • Sildenafil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Patrizi, R., Leonardo, F., Pelliccia, F., Chierchia, S. L., Galetta, P., Cerquetani, E., ... Rosano, G. M. C. (2001). Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers. Italian Heart Journal, 2(11), 841-844.

Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers. / Patrizi, R.; Leonardo, F.; Pelliccia, F.; Chierchia, S. L.; Galetta, P.; Cerquetani, E.; Frascà, F.; Massimo, F.; Rosano, G. M C.

In: Italian Heart Journal, Vol. 2, No. 11, 2001, p. 841-844.

Research output: Contribution to journalArticle

Patrizi, R, Leonardo, F, Pelliccia, F, Chierchia, SL, Galetta, P, Cerquetani, E, Frascà, F, Massimo, F & Rosano, GMC 2001, 'Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers', Italian Heart Journal, vol. 2, no. 11, pp. 841-844.
Patrizi R, Leonardo F, Pelliccia F, Chierchia SL, Galetta P, Cerquetani E et al. Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers. Italian Heart Journal. 2001;2(11):841-844.
Patrizi, R. ; Leonardo, F. ; Pelliccia, F. ; Chierchia, S. L. ; Galetta, P. ; Cerquetani, E. ; Frascà, F. ; Massimo, F. ; Rosano, G. M C. / Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers. In: Italian Heart Journal. 2001 ; Vol. 2, No. 11. pp. 841-844.
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abstract = "Background. It has been suggested that phosphodiesterase 5 (PDE5) inhibition is potentially hazardous and that it increases the risk of cardiac events in patients with coronary artery disease. This study sought to evaluate whether PDE5 inhibition with sildenafil exerts any effect on exercise-induced myocardial ischemia in patients on beta-blockers. Methods. Fourteen patients underwent a baseline exercise test off-therapy and were then started on atenolol (100 mg once daily). After a run-in phase of 1 week, patients underwent a second exercise test and were randomized to receive either sildenafil (50 mg) or placebo given in a random order on two different occasions, 2 days apart. Exercise test was repeated 2 hours after the administration of sildenafil or placebo. Results. All patients had a > 1 mm ST-segment depression while off-therapy. Eight patients had a negative exercise test response after atenolol, which was unaltered by the adjunct of either sildenafil or placebo. In the remaining subjects, atenolol significantly prolonged the time to 1 mm ST-segment depression and the exercise time. Sildenafil and placebo did not reverse the beneficial effect of atenolol upon exercise-induced myocardial ischemia. Conclusions. PDE5 inhibition does not worsen exercise capacity and exercise-induced myocardial ischemia in patients with chronic stable angina whose symptoms and exercise test response are well controlled by beta-blocker therapy.",
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AU - Leonardo, F.

AU - Pelliccia, F.

AU - Chierchia, S. L.

AU - Galetta, P.

AU - Cerquetani, E.

AU - Frascà, F.

AU - Massimo, F.

AU - Rosano, G. M C

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AB - Background. It has been suggested that phosphodiesterase 5 (PDE5) inhibition is potentially hazardous and that it increases the risk of cardiac events in patients with coronary artery disease. This study sought to evaluate whether PDE5 inhibition with sildenafil exerts any effect on exercise-induced myocardial ischemia in patients on beta-blockers. Methods. Fourteen patients underwent a baseline exercise test off-therapy and were then started on atenolol (100 mg once daily). After a run-in phase of 1 week, patients underwent a second exercise test and were randomized to receive either sildenafil (50 mg) or placebo given in a random order on two different occasions, 2 days apart. Exercise test was repeated 2 hours after the administration of sildenafil or placebo. Results. All patients had a > 1 mm ST-segment depression while off-therapy. Eight patients had a negative exercise test response after atenolol, which was unaltered by the adjunct of either sildenafil or placebo. In the remaining subjects, atenolol significantly prolonged the time to 1 mm ST-segment depression and the exercise time. Sildenafil and placebo did not reverse the beneficial effect of atenolol upon exercise-induced myocardial ischemia. Conclusions. PDE5 inhibition does not worsen exercise capacity and exercise-induced myocardial ischemia in patients with chronic stable angina whose symptoms and exercise test response are well controlled by beta-blocker therapy.

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