Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man

F. Puppo, G. F. Adami, G. Corsini, G. M. Zavarise, J. Zattoni

Research output: Contribution to journalArticlepeer-review

Abstract

A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 ng ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P

Original languageEnglish
Pages (from-to)1205-1207
Number of pages3
JournalBritish Journal of Anaesthesia
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 1980

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

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