Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man

F. Puppo, G. F. Adami, G. Corsini, G. M. Zavarise, J. Zattoni

Research output: Contribution to journalArticle

Abstract

A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 ng ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P

Original languageEnglish
Pages (from-to)1205-1207
Number of pages3
JournalBritish Journal of Anaesthesia
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 1980

Fingerprint

barbiturates
phenobarbital
Lymphocytes
Phenobarbital
mouth
Dose
lymphocytes
dosage
lymphocyte proliferation
Lymphocyte Activation
Serum
Mitogens
Pulse width modulation
Drugs
plateaus
drugs
Evaluate
Pharmaceutical Preparations
barbituric acid

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man. / Puppo, F.; Adami, G. F.; Corsini, G.; Zavarise, G. M.; Zattoni, J.

In: British Journal of Anaesthesia, Vol. 52, No. 12, 12.1980, p. 1205-1207.

Research output: Contribution to journalArticle

Puppo, F, Adami, GF, Corsini, G, Zavarise, GM & Zattoni, J 1980, 'Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man', British Journal of Anaesthesia, vol. 52, no. 12, pp. 1205-1207. https://doi.org/10.1093/bja/52.12.1205
Puppo, F. ; Adami, G. F. ; Corsini, G. ; Zavarise, G. M. ; Zattoni, J. / Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man. In: British Journal of Anaesthesia. 1980 ; Vol. 52, No. 12. pp. 1205-1207.
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