Effect of sirolimus-eluting stent in diabetic patients with small coronary arteries (a SES-SMART substudy)

Paolo Ortolani, Diego Ardissino, Claudio Cavallini, Ezio Bramucci, Ciro Indolfi, Matteo Aquilina, Antonio Marzocchi

Research output: Contribution to journalArticle

Abstract

Randomized clinical trials have shown that sirolimus-eluting stents (SESs) decrease restenosis rates compared with bare metal stents (BMSs), but their efficacy among patients who have diabetes mellitus remains to be established. This study investigated the effect of SES implantation in a high-risk population (i.e., patients who had diabetes and small coronary vessel disease). For this purpose, we analyzed outcomes of the subset of patients who had diabetes and were enrolled in the SES-SMART, a randomized trial that compared the results of implantation of SESs and BMSs in small coronary arteries. Twenty-nine patients who had diabetes were originally randomized to receive SESs and 45 patients received BMSs. The use of SESs was associated with ∼60% decreases in the relative incidence of in-segment angiographic restenosis (63% vs 25%, p = 0.003) and in-segment late loss (0.76 vs 0.28 mm, p

Original languageEnglish
Pages (from-to)1393-1398
Number of pages6
JournalThe American Journal of Cardiology
Volume96
Issue number10
DOIs
Publication statusPublished - Nov 15 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ortolani, P., Ardissino, D., Cavallini, C., Bramucci, E., Indolfi, C., Aquilina, M., & Marzocchi, A. (2005). Effect of sirolimus-eluting stent in diabetic patients with small coronary arteries (a SES-SMART substudy). The American Journal of Cardiology, 96(10), 1393-1398. https://doi.org/10.1016/j.amjcard.2005.07.049