Abstract
To further elucidate the role of glucocorticoids in the regulation of leptin secretion, we studied the effects of overnight small doses of dexamethasone on plasma leptin levels in normal weight controls and in obese patients and correlated the results with indexes of insulin sensitivity and body fat distribution. In 114 subjects (81 obese patients, 49 women and 32 men, BMI 37.4±0.77 kg/m2 and 33 normal-weight subjects, 17 women and 16 men, BMI 22.1±0.41 kg/m2) plasma F and leptin levels were measured at 08:00 h basally and after the administration of different doses of dexamethasone (a fixed dose of 1-mg and 0.0035, 0.007, 0.015-mg/kg bw, given p/5 at 23:00 h the night before). Tests were performed one week apart with bw remaining stable over the study period. Basal leptin levels were significantly higher in obese than in normal subjects (31.9±2.41 vs 7.7±0.93 ng/ml, p
| Original language | English |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 26 |
| Issue number | 2 |
| Publication status | Published - Feb 2003 |
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Keywords
- Body fat distribution
- Dexamethasone
- Insulin sensitivity
- Leptin
ASJC Scopus subject areas
- Endocrinology
Cite this
Effect of small doses of dexamethasone on plasma leptin levels in normal and obese subjects : A dose-response study. / Putignano, P.; Brunani, A.; Dubini, A.; Bertolini, M.; Pasquali, R.; Cavagnini, Francesco.
In: Journal of Endocrinological Investigation, Vol. 26, No. 2, 02.2003, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of small doses of dexamethasone on plasma leptin levels in normal and obese subjects
T2 - A dose-response study
AU - Putignano, P.
AU - Brunani, A.
AU - Dubini, A.
AU - Bertolini, M.
AU - Pasquali, R.
AU - Cavagnini, Francesco
PY - 2003/2
Y1 - 2003/2
N2 - To further elucidate the role of glucocorticoids in the regulation of leptin secretion, we studied the effects of overnight small doses of dexamethasone on plasma leptin levels in normal weight controls and in obese patients and correlated the results with indexes of insulin sensitivity and body fat distribution. In 114 subjects (81 obese patients, 49 women and 32 men, BMI 37.4±0.77 kg/m2 and 33 normal-weight subjects, 17 women and 16 men, BMI 22.1±0.41 kg/m2) plasma F and leptin levels were measured at 08:00 h basally and after the administration of different doses of dexamethasone (a fixed dose of 1-mg and 0.0035, 0.007, 0.015-mg/kg bw, given p/5 at 23:00 h the night before). Tests were performed one week apart with bw remaining stable over the study period. Basal leptin levels were significantly higher in obese than in normal subjects (31.9±2.41 vs 7.7±0.93 ng/ml, p
AB - To further elucidate the role of glucocorticoids in the regulation of leptin secretion, we studied the effects of overnight small doses of dexamethasone on plasma leptin levels in normal weight controls and in obese patients and correlated the results with indexes of insulin sensitivity and body fat distribution. In 114 subjects (81 obese patients, 49 women and 32 men, BMI 37.4±0.77 kg/m2 and 33 normal-weight subjects, 17 women and 16 men, BMI 22.1±0.41 kg/m2) plasma F and leptin levels were measured at 08:00 h basally and after the administration of different doses of dexamethasone (a fixed dose of 1-mg and 0.0035, 0.007, 0.015-mg/kg bw, given p/5 at 23:00 h the night before). Tests were performed one week apart with bw remaining stable over the study period. Basal leptin levels were significantly higher in obese than in normal subjects (31.9±2.41 vs 7.7±0.93 ng/ml, p
KW - Body fat distribution
KW - Dexamethasone
KW - Insulin sensitivity
KW - Leptin
UR - http://www.scopus.com/inward/record.url?scp=0037313891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037313891&partnerID=8YFLogxK
M3 - Article
C2 - 12739736
AN - SCOPUS:0037313891
VL - 26
SP - 111
EP - 116
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 2
ER -