Effect of smoking cessation on airway inflammation in chronic bronchitis

G. Turato, A. Di Stefano, P. Maestrelli, C. E. Mapp, M. P. Ruggieri, A. Roggeri, L. M. Fabbri, M. Saetta

Research output: Contribution to journalArticle

Abstract

To investigate the effect of smoking cessation on the airway inflammatory process present in nonatopic subjects with chronic bronchitis, we obtained bronchial biopsies from nine current smokers and seven exsmokers, all with symptoms of chronic bronchitis at the time of the study, and from seven healthy nonsmoking subjects. The exsmokers had stopped smoking on average 13 yr before the study, yet cough and production of sputum had persisted. Bronchial biopsies were assessed using immunohistochemical techniques to investigate the number of inflammatory cells, the markers of mononuclear cell activation, and the expression of endothelial adhesion molecules and cytokines in the subepithelium. Current smokers and exsmokers had an increased number of macrophages, IL-2R-positive cells, VLA-1-positive cells, ICAM-1-positive vessels, and E-selectin-positive vessels compared with normal nonsmoking subjects, but the number of cells positive for neutrophils, EG-2, CD3, CD4, CD8, TNF-α and IL-1β were similar among the three groups. No differences were observed between current smokers and exsmokers for any parameter examined. In conclusion, the inflammatory process present in the airway mucosa of current smokers may persist after smoking cessation in subjects who continue to have symptoms of chronic bronchitis.

Original languageEnglish
Pages (from-to)1262-1267
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume152
Issue number4 I
Publication statusPublished - 1995

Fingerprint

Chronic Bronchitis
Smoking Cessation
Inflammation
Integrin alpha1beta1
Cell Count
Biopsy
E-Selectin
Time and Motion Studies
Intercellular Adhesion Molecule-1
Sputum
Interleukin-1
Cough
Healthy Volunteers
Mucous Membrane
Neutrophils
Smoking
Macrophages
Cytokines

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Turato, G., Di Stefano, A., Maestrelli, P., Mapp, C. E., Ruggieri, M. P., Roggeri, A., ... Saetta, M. (1995). Effect of smoking cessation on airway inflammation in chronic bronchitis. American Journal of Respiratory and Critical Care Medicine, 152(4 I), 1262-1267.

Effect of smoking cessation on airway inflammation in chronic bronchitis. / Turato, G.; Di Stefano, A.; Maestrelli, P.; Mapp, C. E.; Ruggieri, M. P.; Roggeri, A.; Fabbri, L. M.; Saetta, M.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 152, No. 4 I, 1995, p. 1262-1267.

Research output: Contribution to journalArticle

Turato, G, Di Stefano, A, Maestrelli, P, Mapp, CE, Ruggieri, MP, Roggeri, A, Fabbri, LM & Saetta, M 1995, 'Effect of smoking cessation on airway inflammation in chronic bronchitis', American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 4 I, pp. 1262-1267.
Turato, G. ; Di Stefano, A. ; Maestrelli, P. ; Mapp, C. E. ; Ruggieri, M. P. ; Roggeri, A. ; Fabbri, L. M. ; Saetta, M. / Effect of smoking cessation on airway inflammation in chronic bronchitis. In: American Journal of Respiratory and Critical Care Medicine. 1995 ; Vol. 152, No. 4 I. pp. 1262-1267.
@article{6689333c54644acd9690fe6a0736ceeb,
title = "Effect of smoking cessation on airway inflammation in chronic bronchitis",
abstract = "To investigate the effect of smoking cessation on the airway inflammatory process present in nonatopic subjects with chronic bronchitis, we obtained bronchial biopsies from nine current smokers and seven exsmokers, all with symptoms of chronic bronchitis at the time of the study, and from seven healthy nonsmoking subjects. The exsmokers had stopped smoking on average 13 yr before the study, yet cough and production of sputum had persisted. Bronchial biopsies were assessed using immunohistochemical techniques to investigate the number of inflammatory cells, the markers of mononuclear cell activation, and the expression of endothelial adhesion molecules and cytokines in the subepithelium. Current smokers and exsmokers had an increased number of macrophages, IL-2R-positive cells, VLA-1-positive cells, ICAM-1-positive vessels, and E-selectin-positive vessels compared with normal nonsmoking subjects, but the number of cells positive for neutrophils, EG-2, CD3, CD4, CD8, TNF-α and IL-1β were similar among the three groups. No differences were observed between current smokers and exsmokers for any parameter examined. In conclusion, the inflammatory process present in the airway mucosa of current smokers may persist after smoking cessation in subjects who continue to have symptoms of chronic bronchitis.",
author = "G. Turato and {Di Stefano}, A. and P. Maestrelli and Mapp, {C. E.} and Ruggieri, {M. P.} and A. Roggeri and Fabbri, {L. M.} and M. Saetta",
year = "1995",
language = "English",
volume = "152",
pages = "1262--1267",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society - AJRCCM",
number = "4 I",

}

TY - JOUR

T1 - Effect of smoking cessation on airway inflammation in chronic bronchitis

AU - Turato, G.

AU - Di Stefano, A.

AU - Maestrelli, P.

AU - Mapp, C. E.

AU - Ruggieri, M. P.

AU - Roggeri, A.

AU - Fabbri, L. M.

AU - Saetta, M.

PY - 1995

Y1 - 1995

N2 - To investigate the effect of smoking cessation on the airway inflammatory process present in nonatopic subjects with chronic bronchitis, we obtained bronchial biopsies from nine current smokers and seven exsmokers, all with symptoms of chronic bronchitis at the time of the study, and from seven healthy nonsmoking subjects. The exsmokers had stopped smoking on average 13 yr before the study, yet cough and production of sputum had persisted. Bronchial biopsies were assessed using immunohistochemical techniques to investigate the number of inflammatory cells, the markers of mononuclear cell activation, and the expression of endothelial adhesion molecules and cytokines in the subepithelium. Current smokers and exsmokers had an increased number of macrophages, IL-2R-positive cells, VLA-1-positive cells, ICAM-1-positive vessels, and E-selectin-positive vessels compared with normal nonsmoking subjects, but the number of cells positive for neutrophils, EG-2, CD3, CD4, CD8, TNF-α and IL-1β were similar among the three groups. No differences were observed between current smokers and exsmokers for any parameter examined. In conclusion, the inflammatory process present in the airway mucosa of current smokers may persist after smoking cessation in subjects who continue to have symptoms of chronic bronchitis.

AB - To investigate the effect of smoking cessation on the airway inflammatory process present in nonatopic subjects with chronic bronchitis, we obtained bronchial biopsies from nine current smokers and seven exsmokers, all with symptoms of chronic bronchitis at the time of the study, and from seven healthy nonsmoking subjects. The exsmokers had stopped smoking on average 13 yr before the study, yet cough and production of sputum had persisted. Bronchial biopsies were assessed using immunohistochemical techniques to investigate the number of inflammatory cells, the markers of mononuclear cell activation, and the expression of endothelial adhesion molecules and cytokines in the subepithelium. Current smokers and exsmokers had an increased number of macrophages, IL-2R-positive cells, VLA-1-positive cells, ICAM-1-positive vessels, and E-selectin-positive vessels compared with normal nonsmoking subjects, but the number of cells positive for neutrophils, EG-2, CD3, CD4, CD8, TNF-α and IL-1β were similar among the three groups. No differences were observed between current smokers and exsmokers for any parameter examined. In conclusion, the inflammatory process present in the airway mucosa of current smokers may persist after smoking cessation in subjects who continue to have symptoms of chronic bronchitis.

UR - http://www.scopus.com/inward/record.url?scp=0029086408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029086408&partnerID=8YFLogxK

M3 - Article

C2 - 7551380

AN - SCOPUS:0029086408

VL - 152

SP - 1262

EP - 1267

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 4 I

ER -