Effect of smoking on endothelium-independent vasodilatation

Gaetano A. Lanza, Francesco R. Spera, Angelo Villano, Giulio Russo, Antonino Di Franco, Priscilla Lamendola, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background: Smoking induces an impairment of endothelium-dependent vasodilatation. In this study we assessed whether smoking also causes an impairment of endothelium-independent vasodilatation. Methods: We studied 2 groups of young healthy subjects: 1) 12 medical students (24.5±0.9 years; 6 male) without cardiovascular risk factors (CVRFs), except smoking (≥10 cigarettes/day); 2) 12 matched controls (24.5±1.1 years; 6 male) without any CVRF. Nitrate-mediated dilatation (NMD) of the brachial artery was assessed in response to the random administration of 4 different doses (10, 20, 30 and 40μg) of sublingual nitroglycerin (NTG). Flow-mediated dilatation (FMD) was also assessed. Results: The increasing doses of NTG determined a progressive increase of NMD in both groups, but the dose-response curve was significantly lower in smokers compared to controls (p

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalAtherosclerosis
Volume240
Issue number2
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Endothelial function
  • Nitrate-mediated dilatation
  • Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Lanza, G. A., Spera, F. R., Villano, A., Russo, G., Di Franco, A., Lamendola, P., & Crea, F. (2015). Effect of smoking on endothelium-independent vasodilatation. Atherosclerosis, 240(2), 330-332. https://doi.org/10.1016/j.atherosclerosis.2015.03.041