Effect of sodium pool changes on blood pressure in patients undergoing PFD: Design of a prospective randomized multicenter trial

F. Locatelli, S. Andrulli, S. Di Filippo, U. Pozzoli, C. Tetta

Research output: Contribution to journalArticle


Blood pressure control is important during dialysis and the interdialytic period because of the frequency and potential seriousness of hypotension and hypertension. Water and sodium removal play an important role in the genesis of intradialytic cardiovascular instability or hypertension. Changing dialysate sodium concentrations without the aid of a kinetic model can sometimes give good results but is only an empirical approach. Therefore, this clinical trial was designed to prospectively investigate the advantages of changes in the sodium pool on the blood pressure profile of patients undergoing paired filtration dialysis (PFD). The hypothesis to be tested is whether using a dialysate conductivity which, according to the conductivity kinetic model, ensures that the conductivity of the ultrafiltrate at the end of each dialysis session is 0.3 mS/cm more (B) or less (C) than the mean during the run-in period, improves blood pressure control either in patients prone to intradialytic hypotension or patients who are hypertensive or normotensive with antihypertensive treatment. Patients will be randomly allocated to one of two treatment sequences (where treatment A is standard PFD): AABB or ABAA for patients with intradialytic hypotension; AACC or ACAA for hypertensive patients. During the experimental phase arterial blood pressure will be measured and symptoms reported by the patients will be recorded.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalJournal of Nephrology
Issue number3
Publication statusPublished - 2001



  • Blood pressure control
  • Cardiovascular stability
  • Conductivity kinetic model
  • Hemodiafiltration
  • PFD

ASJC Scopus subject areas

  • Nephrology

Cite this