Effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients

M. Peracchi, E. Reschini, L. Cantalamessa, G. Giustina, F. Cavagnini, M. Pinto, P. Bulgheroni

Research output: Contribution to journalArticlepeer-review

Abstract

Synthetic growth-hormone-release inhibitory hormone (GRIH, somatostatin) infused in seven acromegalics significantly lowered plasma growth hormone (GH) and immunoreactive insulin (IRI) levels, did not have any effect on blood glucose, and significantly increased plasma free fatty acids (FFA). Somatostatin, when infused in three normal subjects during an arginine test, inhibited plasma GH and IRI responses. Hypoglycemia-induced GH release was also blocked by somatostatin in two normal subjects thus tested.

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalMetabolism
Volume23
Issue number11
DOIs
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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