Effect of spinal transcutaneous direct current stimulation on somatosensory evoked potentials in humans

Filippo Cogiamanian, Maurizio Vergari, Francesca Pulecchi, Sara Marceglia, Alberto Priori

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Invasive stimulation of the spinal cord is used to treat a number of pathological conditions. Aiming to modulate human spinal cord function non-invasively, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in conduction along the sensory spinal pathways. Methods: Somatosensory evoked potentials (SEPs) by posterior tibial nerve and by median nerve stimulation were recorded, before, at current offset and at 20 min after transcutaneous anodal or cathodal DC stimulation over the thoracic spinal cord (2.5 mA, 15 min) in a group of 12 healthy subjects. Results: Whereas both polarities left the spinal (N22) and the cortical potentials (P39) unchanged, anodal transcutaneous spinal DC stimulation decreased significantly by about 25% the amplitude of the cervico-medullary component of posterior tibial nerve SEPs (P30) for at least 20 min. Thoracic transcutaneous spinal cord stimulation left median nerve SEPs unchanged. Conclusions: Transcutaneous DC stimulation over the thoracic spinal cord induces changes in conduction along human lemniscal pathway that persist after stimulation ends. Significance: Our results support the use of transcutaneous DC stimulation as a novel tool for non-invasive spinal neuromodulation. Because the method is non-expensive and simple, it can be tested in patients with disorders presently treated with invasive procedures.

Original languageEnglish
Pages (from-to)2636-2640
Number of pages5
JournalClinical Neurophysiology
Volume119
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Direct current stimulation
  • SEPs
  • Spinal cord
  • Spinal cord stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

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