Effect of steroid and high-dose immunoglobulin therapy on opsoclonus- myoclonus syndrome occurring in neuroblastoma

E. Veneselli, M. Conte, R. Biancheri, A. Acquaviva, B. De Bernardi

Research output: Contribution to journalArticle


The authors describe a case of an 8-month-old boy with opsoclonus- myoclonus syndrome (OMS) and coincident unresectable neuroblastoma (NB). He achieved a complete remission for NB after 6 courses of standard-dose chemotherapy without significant neurological improvement despite the use of steroids and high-dose immunoglobulin (HIG), administered separately. Only the combined treatment with these two drugs induced a complete disappearance of neurological symptoms. On the basis of this experience, the authors suggest the association of steroids plus HIG for the treatment of OMS in patients not responsive to conventional first line therapy with steroids.

Original languageEnglish
Pages (from-to)15-17
Number of pages3
JournalMedical and Pediatric Oncology
Issue number1
Publication statusPublished - 1997



  • Neuroblastoma
  • Opsomyoclonus syndrome
  • Treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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