The aim of this study was to assess the left ventricular diastolic changes induced by a single sublingual dose of captopril (25 mg) in hypertensive patients. Captopril or placebo were administered according to a double-blind cross-over protocol in 2 consecutive days. Blood pressure measurements and Doppler echocardiographic studies were performed in 20 untreated essential hypertensive patients, before and 30 min after captopril or placebo administration. The following parameters of left ventricular filling were calculated: early peak velocity (E), late peak velocity (A), their ratio (E/A) and velocity integrals. Sublingual captopril promptly and significantly reduced blood pressure in comparison with baseline and placebo (-17/-13 mmHg and -11/-11 mmHg, p <0.01) without affecting heart rate. Afterload reduction by captopril was associated with a favorable modification of Doppler mitral flow pattern reflected by a significant increase in early diastolic filling. These findings suggest that the sublingual captopril may improve diastolic dysfunction and may be used in association with traditional treatment in hypertensive crisis.
|Number of pages||3|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging