Effect of Submucosal Injection of Dexamethasone on Postoperative Discomfort After Third Molar Surgery: A Prospective Study

Giovanni Battista Grossi, Carlo Maiorana, Rocco Alberto Garramone, Andrea Borgonovo, Mario Beretta, Davide Farronato, Franco Santoro

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate the effect of submucosal administration of dexamethasone sodium phosphate on discomfort after mandibular third molar surgery. Patients and Methods: Sixty-one consecutive patients requiring surgical removal of a single mandibular impacted third molar under local anesthesia were randomly placed into 3 groups. After the onset of local anesthesia, the experimental groups received dexamethasone at 2 different doses (4 or 8 mg) as submucosal injection, and the control group received no drug. Standardized surgical and analgesic protocols were followed. Maximum interincisal distance and facial contours were measured at baseline and at postsurgery days 2 and 7. Pain was objectively measured by counting the number of analgesic tablets required. The patients' perception of the severity of symptoms was assessed with a follow-up questionnaire (PoSSe scale). Results: On the second postoperative day, facial edema showed a statistically significant reduction in both dexamethasone 4-mg and dexamethasone 8-mg groups compared with the control group, but no statistically significant differences were observed between the 2 dosage regimens of dexamethasone. By contrast, there was no statistically significant difference between all groups when postoperative swelling was evaluated at day 7 (P > .50). The treatment group had a limited and nonsignificant effect on pain and trismus when compared with the control group at the 2 times of evaluation. Conclusions: Parenteral use of dexamethasone 4 mg, given as an intraoral injection at the time of surgery, is effective in the prevention of postoperative edema. Increasing the dose to 8 mg provides no further benefit.

Original languageEnglish
Pages (from-to)2218-2226
Number of pages9
JournalJournal of Oral and Maxillofacial Surgery
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 2007

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Third Molar
Dexamethasone
Prospective Studies
Injections
dexamethasone 21-phosphate
Local Anesthesia
Control Groups
Analgesics
Edema
Trismus
Pain
Tablets
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dentistry(all)
  • Surgery

Cite this

Effect of Submucosal Injection of Dexamethasone on Postoperative Discomfort After Third Molar Surgery : A Prospective Study. / Grossi, Giovanni Battista; Maiorana, Carlo; Garramone, Rocco Alberto; Borgonovo, Andrea; Beretta, Mario; Farronato, Davide; Santoro, Franco.

In: Journal of Oral and Maxillofacial Surgery, Vol. 65, No. 11, 11.2007, p. 2218-2226.

Research output: Contribution to journalArticle

Grossi, Giovanni Battista ; Maiorana, Carlo ; Garramone, Rocco Alberto ; Borgonovo, Andrea ; Beretta, Mario ; Farronato, Davide ; Santoro, Franco. / Effect of Submucosal Injection of Dexamethasone on Postoperative Discomfort After Third Molar Surgery : A Prospective Study. In: Journal of Oral and Maxillofacial Surgery. 2007 ; Vol. 65, No. 11. pp. 2218-2226.
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