Effect of successful hypertension control by manidipine or lisinopril on albuminuria and left ventricular mass in diabetic hypertensive patients with microalbuminuria

Roberto Fogari, Amedeo Mugellini, Annalisa Zoppi, Pierangelo Lazzari, Maurizio Destro, Andrea Rinaldi, Paola Preti

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Abstract

Objective: The aim of this open-labelled, randomised, parallel-group study was to evaluate the effect of long-term monotherapy with manidipine or lisinopril on albumin excretion rate (AER) and left ventricular mass index (LVMI) in hypertensive patients with type-2 diabetes and microalbuminuria. Methods: After a 4-week wash-out period, 174 patients with essential hypertension [diastolic blood pressure (DBP) >80B mmHg and 80 mmHg); after 3 months, treatment was discontinued in the non-responder patients and in those complaining of side effects; the remaining 121 patients continued their therapy with manidipine or lisinopril, and 99 completed the 2-year study. At the end of the wash-out period, of the titration period and after 6, 12, 18 and 24 months of treatment, BP was measured, AER, creatinine clearance, glycosylated haemoglobin (HbA1c) and body mass index (BMI) were evaluated and an echocardiographic evaluation was performed. Results: The 99 patients who completed the study were statistically analysed according to a per-protocol evaluation. Manidipine and lisinopril significantly reduced systolic blood pressure (SBP) and DBP levels (at 24 months, -22.3/15.5 mmHg, P2 versus -10.8 g/m2 at 24 months). The effect was more pronounced in patients with left ventricular hypertrophy at baseline (-19.8 g/m2 versus -12.8 g/m2, P

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalEuropean Journal of Clinical Pharmacology
Volume61
Issue number7
DOIs
Publication statusPublished - Aug 2005

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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