Effect of tamoxifen in an experimental model of breast tumor studied by dynamic contrast-enhanced magnetic resonance imaging and different contrast agents

Pasquina Marzola, Simona Ramponi, Elena Nicolato, Emanuela Lovati, Marco Sandri, Laura Calderan, Caterina Crescimanno, Flavia Merigo, Andrea Sbarbati, Adriana Grotti, Stefania Vultaggio, Friederich Cavagna, Vito Lorusso, Francesco Osculati

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The aim of this study was to compare the efficacy of gadoteridol, B22956/1 (a new protein binding blood pool contrast agent), and (Gd-DTPA)37-albumin in detecting, by dynamic contrast-enhanced magnetic resonance imaging (MRI), the effect in vivo of tamoxifen in an experimental model of breast tumor implanted in rats. Materials and Methods: Tumors were induced by subcutaneous injection of 106 mammary adenocarcinoma cells (13762 MAT B III). Treatment with tamoxifen (or vehicle) started on day 4 after implantation. On day 10 after implantation, animals were observed by MRI using B22956/1 (or gadoteridol) and, 24 hours later, using (Gd-DTPA)37-albumin. Results: Dynamic contrast-enhanced magnetic resonance imaging data showed that tamoxifen treatment decreased vascular permeability to B22956/1, whereas no difference was detectable in permeability to gadoteridol or to (Gd-DTP A)37-albumin. No effect on fractional plasma volume was detected with either of contrast agents. Conclusions: B22956/1 is superior to both small Gd chelates and macromolecular contrast agents in the assessment of the effect of tamoxifen treatment on tumor vasculature.

Original languageEnglish
Pages (from-to)421-429
Number of pages9
JournalInvestigative Radiology
Volume40
Issue number7
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Angiogenesis
  • Contrast agents
  • DCE-MRI
  • Tamoxifen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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