Effect of tauroursodeoxycholic acid (TUDCA) on biliary lipid composition

M. Muraca, M. T. Vilei, V. Cianci, X. T. Liu

Research output: Contribution to journalArticlepeer-review

Abstract

TUDCA has been proposed in the treatment of hepatobiliary disease, but data on the enrichment of the biliary TUDCA pool and changes of biliary lipids after administration of the compound are scarce. We studied the composition of biliary lipids in a series of 33 patients with radiolucent stones, before and after treatment with TUDCA, 3.5 to 16.6 mg/kg/die for 4-6 weeks. Duodenal bile was collected with the Entero-Test after gallbladder contraction. Cholesterol saturation was 147%+67 before treatment, TUDCA administration produced the following dose-dependent effects: a) a linear decrease of cholesterol saturation (r = 0.59; p); b) a non-linear increase of the percent of ursodeoxycholate in bile (r = 0.59; p); c) a nonlinear increase of the fraction of ursodeoxycholate conjugated with taurine. At the dose of 11 mg/kg per day, cholesterol saturation was 80%, ursodeoxycholic acid represented about 45% of biliary bile acids, and about half of urso was conjugated with taurine. These results can be used as guidelines to assess the required daily dosage of TUDCA.

Original languageEnglish
Pages (from-to)439-440
Number of pages2
JournalItalian Journal of Gastroenterology
Volume27
Issue number8
Publication statusPublished - 1995

Keywords

  • Biliary cholesterol
  • Duodenal bile
  • Gallstones

ASJC Scopus subject areas

  • Gastroenterology

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