Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain

A. Algeri, A. Consolazione, G. Calderini, G. Achilli, E. Puche Canas, S. Garattini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of cerebroventricular injection of [D-Alanine] methionine-enkephalin (DALA), a synthetic analog of met-enkephalin, on the serotonergic system of rat brain has been studied. This opioid peptide caused an increase in 5HT turnover which was particularly evident in the limbic forebrain. This effect was completely antagonized by naloxone pretreatment.

Original languageEnglish
Pages (from-to)1488-1489
Number of pages2
JournalExperientia
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 1978

Fingerprint

Methionine Enkephalin
Enkephalins
Metabolism
Rats
Brain
Serotonin
Opioid Peptides
Naloxone
Prosencephalon
Alanine
Injections
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain. / Algeri, A.; Consolazione, A.; Calderini, G.; Achilli, G.; Canas, E. Puche; Garattini, S.

In: Experientia, Vol. 34, No. 11, 11.1978, p. 1488-1489.

Research output: Contribution to journalArticle

Algeri, A, Consolazione, A, Calderini, G, Achilli, G, Canas, EP & Garattini, S 1978, 'Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain', Experientia, vol. 34, no. 11, pp. 1488-1489. https://doi.org/10.1007/BF01932370
Algeri, A. ; Consolazione, A. ; Calderini, G. ; Achilli, G. ; Canas, E. Puche ; Garattini, S. / Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain. In: Experientia. 1978 ; Vol. 34, No. 11. pp. 1488-1489.
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