Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency

Giuseppe Maschio, Daniele Alberti, Gérard Janin, Francesco Locatelli, Johannes F E Mann, Mario Motolese, Claudio Ponticelli, Eberhard Ritz, Pietro Zucchelli

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Abstract

Background. Drugs that inhibit angiotensin-converting enzyme slow the progression of renal insufficiency in patients with diabetic nephropathy. Whether these drugs have a similar action in patients with other renal diseases is not known. We conducted a study to determine the effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of renal insufficiency in patients with various underlying renal diseases. Methods. In a three-year trial involving 583 patients with renal insufficiency caused by various disorders, 300 patients received benazepril and 283 received placebo. The underlying diseases included glomerulopathies (in 192 patients), interstitial nephritis (in 105), nephrosclerosis (in 97), polycystic kidney disease (in 64), diabetic nephropathy (in 21), and miscellaneous or unknown disorders (in 104). The severity of renal insufficiency was classified according to the base-line creatinine clearance: 227 patients had mild insufficiency (creatinine clearance, 46 to 60 ml per minute), and 356 had moderate insufficiency (creatinine clearance, 30 to 45 ml per minute). The primary end point was a doubling of the base-line serum creatinine concentration or the need for dialysis. Results. At three years, 31 patients in the benazepril group and 57 in the placebo group had reached the primary end point (P

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalNew England Journal of Medicine
Volume334
Issue number15
DOIs
Publication statusPublished - Apr 11 1996

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ASJC Scopus subject areas

  • Medicine(all)

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Maschio, G., Alberti, D., Janin, G., Locatelli, F., Mann, J. F. E., Motolese, M., Ponticelli, C., Ritz, E., & Zucchelli, P. (1996). Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. New England Journal of Medicine, 334(15), 939-945. https://doi.org/10.1056/NEJM199604113341502