Effect of the antiepileptic therapy on olfactory disorders associated with mesial temporal sclerosis

Fabrizia Caminiti, Simona De Salvo, Domenica Nunnari, Placido Bramanti, Rosella Ciurleo, Francesca Granata, Silvia Marino

Research output: Contribution to journalArticle

Abstract

Parosmia has been described in neurological disorders, including temporal epilepsy. We reported a case of parosmia associated with unilateral hyposmia and mesial temporal sclerosis. We assessed the olfactory function by using Sniffin’ sticks test and olfactory event-related potentials (OERPs). The findings of unilateral deficit of identification associated with parosmia only in the side ipsilateral to mesial temporal sclerosis area, that involves temporal olfactory regions responsible for higher level of smell processing, suggest a central genesis of olfactory disorders. The administration of levetiracetam restored olfactory function, OERP N1-P2 amplitude, and mesial temporal sclerosis-related electroencephalographic findings.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNeurocase
DOIs
Publication statusAccepted/In press - Jun 27 2016

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Keywords

  • Levetiracetam
  • mesial sclerosis
  • OERPs
  • parosmia

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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