Abstract
Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.
Original language | English |
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Pages (from-to) | 102-105 |
Number of pages | 4 |
Journal | Psychiatry Investigation |
Volume | 5 |
Issue number | 2 |
Publication status | Published - Jun 2008 |
Keywords
- Antimanic agents
- Bipolar disorder
- Dysbindin
- Pharmacogenetics
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry