Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Dong Hwan Yun; Chi Un Pae; Antonio Drago; Laura Mandelli; Diana De Ronchi; Ashwin A. Patkar; In Ho Paik; Alessandro Serretti; Jung Jin Kim

Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Dong Hwan Yun, Chi Un Pae, Antonio Drago, Laura Mandelli, Diana De Ronchi, Ashwin A. Patkar, In Ho Paik, Alessandro Serretti, Jung Jin Kim

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article

Abstract

Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Psychiatry Investigation
Volume	5
Issue number	2
Publication status	Published - Jun 2008

Keywords

Antimanic agents
Bipolar disorder
Dysbindin
Pharmacogenetics

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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Yun, D. H., Pae, C. U., Drago, A., Mandelli, L., De Ronchi, D., Patkar, A. A., Paik, I. H., Serretti, A., & Kim, J. J. (2008). Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder. Psychiatry Investigation, 5(2), 102-105.

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title = "Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder",

abstract = "Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.",

keywords = "Antimanic agents, Bipolar disorder, Dysbindin, Pharmacogenetics",

author = "Yun, {Dong Hwan} and Pae, {Chi Un} and Antonio Drago and Laura Mandelli and {De Ronchi}, Diana and Patkar, {Ashwin A.} and Paik, {In Ho} and Alessandro Serretti and Kim, {Jung Jin}",

year = "2008",

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language = "English",

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pages = "102--105",

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AU - Yun, Dong Hwan

AU - Pae, Chi Un

AU - Drago, Antonio

AU - Mandelli, Laura

AU - De Ronchi, Diana

AU - Patkar, Ashwin A.

AU - Paik, In Ho

AU - Serretti, Alessandro

AU - Kim, Jung Jin

PY - 2008/6

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N2 - Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.

AB - Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.

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