Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Dong Hwan Yun, Chi Un Pae, Antonio Drago, Laura Mandelli, Diana De Ronchi, Ashwin A. Patkar, In Ho Paik, Alessandro Serretti, Jung Jin Kim

Research output: Contribution to journalArticle

Abstract

Objective We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. Methods A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (± 19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T. rs2005976 G/A, rs760761 C/T and rs2619522 A/C). Results There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. Conclusion Although the small number of subjects is an important limitation in our study. DTNBP1 does not seem to be involved in acute antimanic efficacy.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalPsychiatry Investigation
Volume5
Issue number2
Publication statusPublished - Jun 2008

Keywords

  • Antimanic agents
  • Bipolar disorder
  • Dysbindin
  • Pharmacogenetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Yun, D. H., Pae, C. U., Drago, A., Mandelli, L., De Ronchi, D., Patkar, A. A., Paik, I. H., Serretti, A., & Kim, J. J. (2008). Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder. Psychiatry Investigation, 5(2), 102-105.