Effect of the orally absorbed dopamine analogue N-methyldopamine diisobutyric ester on plasma prolactin levels

G. Lombardi, A. Tommaselli, C. Fariello, A. Quattrone, L. Annunziato

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the diisobutyric ester of N-methyldopamine (Ibopamine) on plasma prolactin levels was investigated in normoprolactinaemic subjects and in hyperprolactinaemic patients with prolactin-secreting tumours or idiopathic hyperprolactinaemia. In hyperprolactinaemic states oral Ibopamine 50 mg induced a significant decrease in elevated plasma prolactin (PRL) levels, 30, 60 and 90 min after administration. The peak effect occurred at 90 min when the mean PRL level was 61% of its basal values.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1983

Keywords

  • dopamine agonist
  • female volunteers
  • hyperprolactinaemia
  • ibopamine
  • prolactin inhibition
  • prolactin-secreting adenoma

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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