Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy

Liffert Vogt; Carlos Chiurchiu; Harbajan Chadha-Boreham; Parisa Danaietash; Jasper Dingemanse; Samy Hadjadj; Henry Krum; Gerjan Navis; Eric Neuhart; Aneliya I. Parvanova; Piero Ruggenenti; Arend Jan Woittiez; Reuven Zimlichman; Giuseppe Remuzzi; Dick De Zeeuw

doi:10.1161/HYPERTENSIONAHA.109.149559

Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy

Liffert Vogt, Carlos Chiurchiu, Harbajan Chadha-Boreham, Parisa Danaietash, Jasper Dingemanse, Samy Hadjadj, Henry Krum, Gerjan Navis, Eric Neuhart, Aneliya I. Parvanova, Piero Ruggenenti, Arend Jan Woittiez, Reuven Zimlichman, Giuseppe Remuzzi, Dick De Zeeuw

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and 135 and 85 and

Original language	English
Pages (from-to)	1206-1209
Number of pages	4
Journal	Hypertension
Volume	55
Issue number	5
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.109.149559
Publication status	Published - May 2010

Keywords

Albuminuria
Diabetic nephropathy
Hypertension
Palosuran
RAAS blockade
Urotensin antagonist

ASJC Scopus subject areas

Internal Medicine

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Vogt, L., Chiurchiu, C., Chadha-Boreham, H., Danaietash, P., Dingemanse, J., Hadjadj, S., Krum, H., Navis, G., Neuhart, E., Parvanova, A. I., Ruggenenti, P., Woittiez, A. J., Zimlichman, R., Remuzzi, G., & De Zeeuw, D. (2010). Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. Hypertension, 55(5), 1206-1209. https://doi.org/10.1161/HYPERTENSIONAHA.109.149559

Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. / Vogt, Liffert; Chiurchiu, Carlos; Chadha-Boreham, Harbajan; Danaietash, Parisa; Dingemanse, Jasper; Hadjadj, Samy; Krum, Henry; Navis, Gerjan; Neuhart, Eric; Parvanova, Aneliya I.; Ruggenenti, Piero; Woittiez, Arend Jan; Zimlichman, Reuven; Remuzzi, Giuseppe; De Zeeuw, Dick.

In: Hypertension, Vol. 55, No. 5, 05.2010, p. 1206-1209.

Research output: Contribution to journal › Article › peer-review

Vogt, L, Chiurchiu, C, Chadha-Boreham, H, Danaietash, P, Dingemanse, J, Hadjadj, S, Krum, H, Navis, G, Neuhart, E, Parvanova, AI, Ruggenenti, P, Woittiez, AJ, Zimlichman, R, Remuzzi, G & De Zeeuw, D 2010, 'Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy', Hypertension, vol. 55, no. 5, pp. 1206-1209. https://doi.org/10.1161/HYPERTENSIONAHA.109.149559

Vogt, Liffert ; Chiurchiu, Carlos ; Chadha-Boreham, Harbajan ; Danaietash, Parisa ; Dingemanse, Jasper ; Hadjadj, Samy ; Krum, Henry ; Navis, Gerjan ; Neuhart, Eric ; Parvanova, Aneliya I. ; Ruggenenti, Piero ; Woittiez, Arend Jan ; Zimlichman, Reuven ; Remuzzi, Giuseppe ; De Zeeuw, Dick. / Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. In: Hypertension. 2010 ; Vol. 55, No. 5. pp. 1206-1209.

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