Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy

Liffert Vogt, Carlos Chiurchiu, Harbajan Chadha-Boreham, Parisa Danaietash, Jasper Dingemanse, Samy Hadjadj, Henry Krum, Gerjan Navis, Eric Neuhart, Aneliya I. Parvanova, Piero Ruggenenti, Arend Jan Woittiez, Reuven Zimlichman, Giuseppe Remuzzi, Dick De Zeeuw

Research output: Contribution to journalArticle

Abstract

The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and 135 and 85 and

Original languageEnglish
Pages (from-to)1206-1209
Number of pages4
JournalHypertension
Volume55
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

Urotensins
Diabetic Nephropathies
Albuminuria
Renin-Angiotensin System
Cross-Over Studies
Albumins
Placebos
Blood Pressure
1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea

Keywords

  • Albuminuria
  • Diabetic nephropathy
  • Hypertension
  • Palosuran
  • RAAS blockade
  • Urotensin antagonist

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Vogt, L., Chiurchiu, C., Chadha-Boreham, H., Danaietash, P., Dingemanse, J., Hadjadj, S., ... De Zeeuw, D. (2010). Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. Hypertension, 55(5), 1206-1209. https://doi.org/10.1161/HYPERTENSIONAHA.109.149559

Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. / Vogt, Liffert; Chiurchiu, Carlos; Chadha-Boreham, Harbajan; Danaietash, Parisa; Dingemanse, Jasper; Hadjadj, Samy; Krum, Henry; Navis, Gerjan; Neuhart, Eric; Parvanova, Aneliya I.; Ruggenenti, Piero; Woittiez, Arend Jan; Zimlichman, Reuven; Remuzzi, Giuseppe; De Zeeuw, Dick.

In: Hypertension, Vol. 55, No. 5, 05.2010, p. 1206-1209.

Research output: Contribution to journalArticle

Vogt, L, Chiurchiu, C, Chadha-Boreham, H, Danaietash, P, Dingemanse, J, Hadjadj, S, Krum, H, Navis, G, Neuhart, E, Parvanova, AI, Ruggenenti, P, Woittiez, AJ, Zimlichman, R, Remuzzi, G & De Zeeuw, D 2010, 'Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy', Hypertension, vol. 55, no. 5, pp. 1206-1209. https://doi.org/10.1161/HYPERTENSIONAHA.109.149559
Vogt, Liffert ; Chiurchiu, Carlos ; Chadha-Boreham, Harbajan ; Danaietash, Parisa ; Dingemanse, Jasper ; Hadjadj, Samy ; Krum, Henry ; Navis, Gerjan ; Neuhart, Eric ; Parvanova, Aneliya I. ; Ruggenenti, Piero ; Woittiez, Arend Jan ; Zimlichman, Reuven ; Remuzzi, Giuseppe ; De Zeeuw, Dick. / Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. In: Hypertension. 2010 ; Vol. 55, No. 5. pp. 1206-1209.
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