Abstract
The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and 135 and 85 and
| Original language | English |
|---|---|
| Pages (from-to) | 1206-1209 |
| Number of pages | 4 |
| Journal | Hypertension |
| Volume | 55 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2010 |
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Keywords
- Albuminuria
- Diabetic nephropathy
- Hypertension
- Palosuran
- RAAS blockade
- Urotensin antagonist
ASJC Scopus subject areas
- Internal Medicine
Cite this
Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy. / Vogt, Liffert; Chiurchiu, Carlos; Chadha-Boreham, Harbajan; Danaietash, Parisa; Dingemanse, Jasper; Hadjadj, Samy; Krum, Henry; Navis, Gerjan; Neuhart, Eric; Parvanova, Aneliya I.; Ruggenenti, Piero; Woittiez, Arend Jan; Zimlichman, Reuven; Remuzzi, Giuseppe; De Zeeuw, Dick.
In: Hypertension, Vol. 55, No. 5, 05.2010, p. 1206-1209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy
AU - Vogt, Liffert
AU - Chiurchiu, Carlos
AU - Chadha-Boreham, Harbajan
AU - Danaietash, Parisa
AU - Dingemanse, Jasper
AU - Hadjadj, Samy
AU - Krum, Henry
AU - Navis, Gerjan
AU - Neuhart, Eric
AU - Parvanova, Aneliya I.
AU - Ruggenenti, Piero
AU - Woittiez, Arend Jan
AU - Zimlichman, Reuven
AU - Remuzzi, Giuseppe
AU - De Zeeuw, Dick
PY - 2010/5
Y1 - 2010/5
N2 - The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and 135 and 85 and
AB - The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and 135 and 85 and
KW - Albuminuria
KW - Diabetic nephropathy
KW - Hypertension
KW - Palosuran
KW - RAAS blockade
KW - Urotensin antagonist
UR - http://www.scopus.com/inward/record.url?scp=77951497845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951497845&partnerID=8YFLogxK
U2 - 10.1161/HYPERTENSIONAHA.109.149559
DO - 10.1161/HYPERTENSIONAHA.109.149559
M3 - Article
C2 - 20231521
AN - SCOPUS:77951497845
VL - 55
SP - 1206
EP - 1209
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 5
ER -