Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter

Research output: Contribution to journalArticle

Abstract

The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.

Original languageEnglish
Pages (from-to)304-309
Number of pages6
JournalNeuroscience Letters
Volume434
Issue number3
DOIs
Publication statusPublished - Apr 4 2008

Keywords

  • Estrogen receptor alpha
  • Morphometry
  • MR
  • Neuroimaging
  • VBM
  • XbaI

ASJC Scopus subject areas

  • Neuroscience(all)

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