Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter

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Abstract

The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.

Original languageEnglish
Pages (from-to)304-309
Number of pages6
JournalNeuroscience Letters
Volume434
Issue number3
DOIs
Publication statusPublished - Apr 4 2008

Fingerprint

Estrogen Receptor alpha
Alleles
Cerebral Cortex
Occipital Lobe
Cerebellar Cortex
Confounding Factors (Epidemiology)
Temporal Lobe
Genes
Alzheimer Disease
Magnetic Resonance Spectroscopy
Pathology
Gray Matter

Keywords

  • Estrogen receptor alpha
  • Morphometry
  • MR
  • Neuroimaging
  • VBM
  • XbaI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter",
abstract = "The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28{\%} of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.",
keywords = "Estrogen receptor alpha, Morphometry, MR, Neuroimaging, VBM, XbaI",
author = "Marina Boccardi and Catia Scassellati and Roberta Ghidoni and Cristina Testa and Luisa Benussi and Matteo Bonetti and Luisella Bocchio-Chiavetto and Massimo Gennarelli and Giuliano Binetti and Frisoni, {Giovanni B.}",
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T1 - Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter

AU - Boccardi, Marina

AU - Scassellati, Catia

AU - Ghidoni, Roberta

AU - Testa, Cristina

AU - Benussi, Luisa

AU - Bonetti, Matteo

AU - Bocchio-Chiavetto, Luisella

AU - Gennarelli, Massimo

AU - Binetti, Giuliano

AU - Frisoni, Giovanni B.

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N2 - The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.

AB - The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.

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