Abstract
The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.
| Original language | English |
|---|---|
| Pages (from-to) | 304-309 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 434 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 4 2008 |
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Keywords
- Estrogen receptor alpha
- Morphometry
- MR
- Neuroimaging
- VBM
- XbaI
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter. / Boccardi, Marina; Scassellati, Catia; Ghidoni, Roberta; Testa, Cristina; Benussi, Luisa; Bonetti, Matteo; Bocchio-Chiavetto, Luisella; Gennarelli, Massimo; Binetti, Giuliano; Frisoni, Giovanni B.
In: Neuroscience Letters, Vol. 434, No. 3, 04.04.2008, p. 304-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
AU - Boccardi, Marina
AU - Scassellati, Catia
AU - Ghidoni, Roberta
AU - Testa, Cristina
AU - Benussi, Luisa
AU - Bonetti, Matteo
AU - Bocchio-Chiavetto, Luisella
AU - Gennarelli, Massimo
AU - Binetti, Giuliano
AU - Frisoni, Giovanni B.
PY - 2008/4/4
Y1 - 2008/4/4
N2 - The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.
AB - The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28% of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm3; 3.17; 14, -94, -38) and cerebral cortex, in particular in the occipital lobe (272 mm3; 3.76; -38,-68,-16), in the middle frontal gyrus (192 mm3; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.
KW - Estrogen receptor alpha
KW - Morphometry
KW - MR
KW - Neuroimaging
KW - VBM
KW - XbaI
UR - http://www.scopus.com/inward/record.url?scp=40849115969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40849115969&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2008.01.076
DO - 10.1016/j.neulet.2008.01.076
M3 - Article
C2 - 18342444
AN - SCOPUS:40849115969
VL - 434
SP - 304
EP - 309
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -