Effect of therapy with streptokinase, diltiazem, and heparin on ventricular arrhythmias in unstable angina

Luigi Oltrona, Piera A. Merlini, Lauretta M. Ladelli, Dario Granata, Michele Lombardo, Mariagrazia Dossena, Marco Sali, Luigi Campolo, Carlo Belli

Research output: Contribution to journalArticle

Abstract

We evaluated the effect of three different anti-ischemic therapeutic regimens on ventricular arrhythmias in 25 patients hospitalized for unstable angina. All patients were randomized to receive (in addition to infusion of heparin, diltiazem, and nitrates), either placebo, or streptokinase (SK) 1,500,000 U in 1 h, or SK 250,000 U in 30 min followed by 100,000 U/h for 48 h. Patients underwent ECG monitoring during the first 72 h after admission and for 24 h after 15 days of oral therapy with diltiazem, aspirin, and transdermal nitrates. Premature ventricular complexes (PVC) and ventricular tachycardia episodes (VT) were significantly reduced during the early phase of hospitalization and after 15 days, in patients treated with prolonged SK infusion. Ventricular arrhythmias are a frequent finding in unstable angina: they are correlated neither to the severity of coronary disease nor to ventricular function; prolonged infusion of SK added to heparin, diltiazem, and nitrates seems to reduce the number and severity of ventricular arrhythmias.

Original languageEnglish
Pages (from-to)S61-S63
JournalJournal of Cardiovascular Pharmacology
Volume18
Publication statusPublished - 1991

Keywords

  • Diltiazem
  • Heparin
  • Streptokinase
  • Unstable angina
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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  • Cite this

    Oltrona, L., Merlini, P. A., Ladelli, L. M., Granata, D., Lombardo, M., Dossena, M., Sali, M., Campolo, L., & Belli, C. (1991). Effect of therapy with streptokinase, diltiazem, and heparin on ventricular arrhythmias in unstable angina. Journal of Cardiovascular Pharmacology, 18, S61-S63.