Effect of three serotonin antagonists on plasma prolactin response to suckling in puerperal women

P. G. Crosignani; G. C. Lombroso; A. Mattei; A. Caccamo; L. Trojsi

Effect of three serotonin antagonists on plasma prolactin response to suckling in puerperal women

P. G. Crosignani, G. C. Lombroso, A. Mattei, A. Caccamo, L. Trojsi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished that PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs.

Original language	English
Pages (from-to)	335-337
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	48
Issue number	2
Publication status	Published - 1979

ASJC Scopus subject areas

Biochemistry
Endocrinology, Diabetes and Metabolism

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abstract = "The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished that PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs.",

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year = "1979",

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AU - Crosignani, P. G.

AU - Lombroso, G. C.

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AU - Caccamo, A.

AU - Trojsi, L.

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N2 - The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished that PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs.

AB - The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished that PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs.

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