Effect of thymoleptics on fenfluramine-induced depletion of brain serotonin in rats

D. Ghezzi, R. Samanin, S. Bernasconi, G. Tognoni, M. Gerna, S. Garattini

Research output: Contribution to journalArticle

Abstract

d,l-Fenfluramine, l-fenfluramine, and l-norfenfluramine produced marked, comparable decreases in brain serotonin. The depletion of brain 5HT induced by fenfluramine was antagonized by chlorimipramine (Cl-IMI) but not by imipramine or desipramine. The effect of Cl-IMI was apparantly not related to major changes in the concentrations of brain fenfluramine or norfenfluramine. This antagonism by Cl-IMI was also observed in 3 different brain areas and at varying time intervals after fenfluramine injection. l-Fenfluramine and l-norfenfluramine were similarly antagonized by chlorimipramine. The anorectic effect of l-fenfluramine was also antagonized by pretreatment with Cl-IMI. The results further support the hypothesis of a direct interaction of fenfluramine with the serotonergic system in the brain.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalEuropean Journal of Pharmacology
Volume24
Issue number2
DOIs
Publication statusPublished - 1973

Keywords

  • Anorexia
  • Chlorimipramine
  • Desipramine
  • Fenfluramine
  • Imipramine
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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