d,l-Fenfluramine, l-fenfluramine, and l-norfenfluramine produced marked, comparable decreases in brain serotonin. The depletion of brain 5HT induced by fenfluramine was antagonized by chlorimipramine (Cl-IMI) but not by imipramine or desipramine. The effect of Cl-IMI was apparantly not related to major changes in the concentrations of brain fenfluramine or norfenfluramine. This antagonism by Cl-IMI was also observed in 3 different brain areas and at varying time intervals after fenfluramine injection. l-Fenfluramine and l-norfenfluramine were similarly antagonized by chlorimipramine. The anorectic effect of l-fenfluramine was also antagonized by pretreatment with Cl-IMI. The results further support the hypothesis of a direct interaction of fenfluramine with the serotonergic system in the brain.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience