Effect of thymosin alpha 1 on mouse thymocyte proliferation

G. Stirparo, D. Sbariglia, L. Frati, C. Rinaldi-Garaci

Research output: Contribution to journalArticlepeer-review


We studied the effect of Thymosin alpha 1 (Tal) on submitogenic proliferation of thymocytes derived from C57 BL/6 mice. Ta1 is a chemically synthesized polypeptide component of Thymosin Fraction 5 extracted from calf thymus. Here, we find the Ta1 markedly increases the proliferation of unfractionated thymocytes but has no effect on the proliferation of thymic subpopulations fractionated by Peanut Agglutinin separation procedure into PNA + and PNA-cells. The association of PNA+ and PNA- subsets restores the sensitivity of thymocytes to Ta1. These data suggest a cooperative phenomenon between the thymic subpopulations (PNA+ and PNA- cells) in respons to Ta1, seemingly for what concerns the increase of proliferation.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmacology

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