We studied the effect of Thymosin alpha 1 (Tal) on submitogenic proliferation of thymocytes derived from C57 BL/6 mice. Ta1 is a chemically synthesized polypeptide component of Thymosin Fraction 5 extracted from calf thymus. Here, we find the Ta1 markedly increases the proliferation of unfractionated thymocytes but has no effect on the proliferation of thymic subpopulations fractionated by Peanut Agglutinin separation procedure into PNA + and PNA-cells. The association of PNA+ and PNA- subsets restores the sensitivity of thymocytes to Ta1. These data suggest a cooperative phenomenon between the thymic subpopulations (PNA+ and PNA- cells) in respons to Ta1, seemingly for what concerns the increase of proliferation.
|Number of pages||6|
|Journal||International Journal of Immunopathology and Pharmacology|
|Publication status||Published - 1990|
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