Effect of thyroid hormones on androgen responsiveness in a mammary tumor cell line

G. Sica, C. Natoli, P. Marchetti, S. Iacobelli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Androgen sensitive cells derived from the androgen responsive Shionogi 115 mouse mammary carcinoma, when cultured for 4 weeks in testosterone free medium lose their androgen responsiveness. Thyroid hormones influence this loss of steroid sensitivity especially if cells are cultured in medium supplemented with serum treated with AG1 × 10 resin which specifically removes thyroid hormones from it. These hormones slow down the loss of androgen responsiveness, maintaining the cells more responsive to the stimulatory effect of testosterone, without producing any detectable change in androgen receptor content. As the transition to androgen unresponsive status is accompanied in S 115 cells by profound changes in cell morphology, it is reasonable to hypothesize that thyroid hormones exert their effect through modifications of cell membrane properties.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalJournal of Steroid Biochemistry
Volume15
Issue numberC
DOIs
Publication statusPublished - 1981

Fingerprint

Tumor Cell Line
Thyroid Hormones
Androgens
Tumors
Cells
Breast Neoplasms
Testosterone
Androgen Receptors
Cell membranes
Cultured Cells
Resins
Steroids
Cell Membrane
Hormones
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Effect of thyroid hormones on androgen responsiveness in a mammary tumor cell line. / Sica, G.; Natoli, C.; Marchetti, P.; Iacobelli, S.

In: Journal of Steroid Biochemistry, Vol. 15, No. C, 1981, p. 415-419.

Research output: Contribution to journalArticle

Sica, G. ; Natoli, C. ; Marchetti, P. ; Iacobelli, S. / Effect of thyroid hormones on androgen responsiveness in a mammary tumor cell line. In: Journal of Steroid Biochemistry. 1981 ; Vol. 15, No. C. pp. 415-419.
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