Abstract
Aims and background: The question of whether TPN is able to reverse lean body mass depletion in cachectic cancer patients and, in particular, its effect on protein kinetics is a matter of some controversy. This study investigates the impact of TPN on protein kinetics in patients with gastric cancer. Methods: The study involved three patients with 14-30% weight loss. They were administered a TPN regimen including 33-40 kcal/kg/day and 1.4-1.7 g amino acid/kg/day. The protein metabolism was studied before and during TPN using a stable amino acid isotope. Results: Whole body protein turnover and breakdown did not change during TPN, whereas whole body protein synthesis increased from 3.39 ± 1.04 to 6.05 ± 0.48 g/kg/day (P = 0.03). However, the net balance, which was slightly negative prior to TPN, became positive during nutritional support. In the skeletal muscle compartment the synthesis improved with TPN (from 9.38 ± 2.6 nmol/100 mL/min to 35.95 ± 3.4 nmol/100 mL/min; P = 0.0143), whereas breakdown did not change significantly. Conclusions: TPN triggers a positive metabolic response in cachectic cancer patients. Whether this results in a clinical benefit for the patient requires further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 408-411 |
| Number of pages | 4 |
| Journal | Tumori |
| Volume | 86 |
| Issue number | 5 |
| Publication status | Published - 2000 |
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Keywords
- Muscle protein metabolism
- Nutritional support
- Protein metabolism
- Total parenteral nutrition
ASJC Scopus subject areas
- Cancer Research
Cite this
Effect of total parenteral nutrition on the protein kinetics of patients with cancer cachexia. / Bozzetti, F.; Gavazzi, C.; Ferrari, P.; Dworzak, F.
In: Tumori, Vol. 86, No. 5, 2000, p. 408-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of total parenteral nutrition on the protein kinetics of patients with cancer cachexia
AU - Bozzetti, F.
AU - Gavazzi, C.
AU - Ferrari, P.
AU - Dworzak, F.
PY - 2000
Y1 - 2000
N2 - Aims and background: The question of whether TPN is able to reverse lean body mass depletion in cachectic cancer patients and, in particular, its effect on protein kinetics is a matter of some controversy. This study investigates the impact of TPN on protein kinetics in patients with gastric cancer. Methods: The study involved three patients with 14-30% weight loss. They were administered a TPN regimen including 33-40 kcal/kg/day and 1.4-1.7 g amino acid/kg/day. The protein metabolism was studied before and during TPN using a stable amino acid isotope. Results: Whole body protein turnover and breakdown did not change during TPN, whereas whole body protein synthesis increased from 3.39 ± 1.04 to 6.05 ± 0.48 g/kg/day (P = 0.03). However, the net balance, which was slightly negative prior to TPN, became positive during nutritional support. In the skeletal muscle compartment the synthesis improved with TPN (from 9.38 ± 2.6 nmol/100 mL/min to 35.95 ± 3.4 nmol/100 mL/min; P = 0.0143), whereas breakdown did not change significantly. Conclusions: TPN triggers a positive metabolic response in cachectic cancer patients. Whether this results in a clinical benefit for the patient requires further investigation.
AB - Aims and background: The question of whether TPN is able to reverse lean body mass depletion in cachectic cancer patients and, in particular, its effect on protein kinetics is a matter of some controversy. This study investigates the impact of TPN on protein kinetics in patients with gastric cancer. Methods: The study involved three patients with 14-30% weight loss. They were administered a TPN regimen including 33-40 kcal/kg/day and 1.4-1.7 g amino acid/kg/day. The protein metabolism was studied before and during TPN using a stable amino acid isotope. Results: Whole body protein turnover and breakdown did not change during TPN, whereas whole body protein synthesis increased from 3.39 ± 1.04 to 6.05 ± 0.48 g/kg/day (P = 0.03). However, the net balance, which was slightly negative prior to TPN, became positive during nutritional support. In the skeletal muscle compartment the synthesis improved with TPN (from 9.38 ± 2.6 nmol/100 mL/min to 35.95 ± 3.4 nmol/100 mL/min; P = 0.0143), whereas breakdown did not change significantly. Conclusions: TPN triggers a positive metabolic response in cachectic cancer patients. Whether this results in a clinical benefit for the patient requires further investigation.
KW - Muscle protein metabolism
KW - Nutritional support
KW - Protein metabolism
KW - Total parenteral nutrition
UR - http://www.scopus.com/inward/record.url?scp=0033695705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033695705&partnerID=8YFLogxK
M3 - Article
VL - 86
SP - 408
EP - 411
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 5
ER -