Abstract
Training has many beneficial effects, however few studies report its effects on the lungs. The aim of this study was to assess the effects of acute exercise and exercise training on inflammatory responses and remodeling in central and peripheral airways. Sixteen Sprague-Dawley rats trained for 10weeks, while 14 rats served as controls. Before sacrifice, 8 trained (TR AC) and 8 untrained control (CON AC) rats underwent a single acute exercise bout, while 8 trained (TR) and 6 untrained control (CON) rats were sacrificed without acute exercise. The central and peripheral airways were morphologically examined for inflammatory cells and immunostained for decorin, collagen I, α-smooth muscle actin. No significant differences were found for morphometric analysis in central and peripheral airways, however CON AC showed a significant increase in polymorphonuclear cells in the central airways compared to CON. In contrast, TR AC did not show an inflammatory response different from TR. A similar trend was present in peripheral airways. Training did not induce differences in airways inflammation and remodeling as compared to CON. However, training seemed to limit the inflammatory response induced by acute exercise in the central airways.
| Original language | English |
|---|---|
| Pages (from-to) | 181-186 |
| Number of pages | 6 |
| Journal | Respiratory Physiology and Neurobiology |
| Volume | 179 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Dec 15 2011 |
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Keywords
- α-SMA
- Decorin
- Exercise
- Inflammatory cells
- Proteoglycans
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
- Neuroscience(all)
Cite this
Effect of training on airways inflammatory response and remodeling in a rat model. / Pini, Laura; Novali, Mauro; Modina, Denise; Torregiani, Chiara; Ludwig, Mara S.; Veicsteinas, Arsenio; Esposito, Fabio.
In: Respiratory Physiology and Neurobiology, Vol. 179, No. 2-3, 15.12.2011, p. 181-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of training on airways inflammatory response and remodeling in a rat model
AU - Pini, Laura
AU - Novali, Mauro
AU - Modina, Denise
AU - Torregiani, Chiara
AU - Ludwig, Mara S.
AU - Veicsteinas, Arsenio
AU - Esposito, Fabio
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Training has many beneficial effects, however few studies report its effects on the lungs. The aim of this study was to assess the effects of acute exercise and exercise training on inflammatory responses and remodeling in central and peripheral airways. Sixteen Sprague-Dawley rats trained for 10weeks, while 14 rats served as controls. Before sacrifice, 8 trained (TR AC) and 8 untrained control (CON AC) rats underwent a single acute exercise bout, while 8 trained (TR) and 6 untrained control (CON) rats were sacrificed without acute exercise. The central and peripheral airways were morphologically examined for inflammatory cells and immunostained for decorin, collagen I, α-smooth muscle actin. No significant differences were found for morphometric analysis in central and peripheral airways, however CON AC showed a significant increase in polymorphonuclear cells in the central airways compared to CON. In contrast, TR AC did not show an inflammatory response different from TR. A similar trend was present in peripheral airways. Training did not induce differences in airways inflammation and remodeling as compared to CON. However, training seemed to limit the inflammatory response induced by acute exercise in the central airways.
AB - Training has many beneficial effects, however few studies report its effects on the lungs. The aim of this study was to assess the effects of acute exercise and exercise training on inflammatory responses and remodeling in central and peripheral airways. Sixteen Sprague-Dawley rats trained for 10weeks, while 14 rats served as controls. Before sacrifice, 8 trained (TR AC) and 8 untrained control (CON AC) rats underwent a single acute exercise bout, while 8 trained (TR) and 6 untrained control (CON) rats were sacrificed without acute exercise. The central and peripheral airways were morphologically examined for inflammatory cells and immunostained for decorin, collagen I, α-smooth muscle actin. No significant differences were found for morphometric analysis in central and peripheral airways, however CON AC showed a significant increase in polymorphonuclear cells in the central airways compared to CON. In contrast, TR AC did not show an inflammatory response different from TR. A similar trend was present in peripheral airways. Training did not induce differences in airways inflammation and remodeling as compared to CON. However, training seemed to limit the inflammatory response induced by acute exercise in the central airways.
KW - α-SMA
KW - Decorin
KW - Exercise
KW - Inflammatory cells
KW - Proteoglycans
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UR - http://www.scopus.com/inward/citedby.url?scp=81155152403&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2011.08.001
DO - 10.1016/j.resp.2011.08.001
M3 - Article
C2 - 21855658
AN - SCOPUS:81155152403
VL - 179
SP - 181
EP - 186
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 2-3
ER -