Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease

Maria Cotelli, Rosa Manenti, Stefano F. Cappa, Cristina Geroldi, Orazio Zanetti, Paolo M. Rossini, Carlo Miniussi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). Design: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients: Fifteen patients with probable AD. Intervention: High-frequency rTMS was applied to the left and right DLPFC during object and action naming. Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS. Results: Stimulation to the left and right DLPFC improved accuracy in action naming. Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.

Original languageEnglish
Pages (from-to)1602-1604
Number of pages3
JournalArchives of Neurology
Volume63
Issue number11
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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