Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease

Research output: Contribution to journalArticle

Abstract

Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). Design: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients: Fifteen patients with probable AD. Intervention: High-frequency rTMS was applied to the left and right DLPFC during object and action naming. Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS. Results: Stimulation to the left and right DLPFC improved accuracy in action naming. Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.

Original languageEnglish
Pages (from-to)1602-1604
Number of pages3
JournalArchives of Neurology
Volume63
Issue number11
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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