TY - JOUR
T1 - Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease
AU - Cotelli, Maria
AU - Manenti, Rosa
AU - Cappa, Stefano F.
AU - Geroldi, Cristina
AU - Zanetti, Orazio
AU - Rossini, Paolo M.
AU - Miniussi, Carlo
PY - 2006/11
Y1 - 2006/11
N2 - Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). Design: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients: Fifteen patients with probable AD. Intervention: High-frequency rTMS was applied to the left and right DLPFC during object and action naming. Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS. Results: Stimulation to the left and right DLPFC improved accuracy in action naming. Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.
AB - Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). Design: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients: Fifteen patients with probable AD. Intervention: High-frequency rTMS was applied to the left and right DLPFC during object and action naming. Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS. Results: Stimulation to the left and right DLPFC improved accuracy in action naming. Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.
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U2 - 10.1001/archneur.63.11.1602
DO - 10.1001/archneur.63.11.1602
M3 - Article
C2 - 17101829
AN - SCOPUS:33750981228
VL - 63
SP - 1602
EP - 1604
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 11
ER -