TY - JOUR
T1 - Effect of TT virus infection on hepatocellular carcinoma development
T2 - Results of a Euro-Asian survey
AU - Pineau, Pascal
AU - Meddeb, Mounira
AU - Raselli, Roberta
AU - Qin, Lun Xiu
AU - Terris, Benoît
AU - Tang, Zhao You
AU - Tiollais, Pierre
AU - Mazzaferro, Vincenzo
AU - Dejean, Anne
PY - 2000
Y1 - 2000
N2 - A small percentage of persons with hepatocellular carcinoma (HCC) lack identifiable causes of liver pathology. The single-stranded DNA virus, TT virus (TTV), has been found in persons with acute and chronic liver injury. Nested polymerase chain reaction was used to search for both TTV and parvoviruses in 293 HCC samples from Asia and Europe. TTV was found in >30% of Chinese and Italian samples but in only 13% of French samples. No clinicopathologic differences were found between TTV-positive and -negative populations. A significant association was found between TTV infection and hepatitis B virus (P <.01) and herpesviruses (P <.02) in HCC patients, suggesting that factors promoting these infections are associated with enhanced TTV positivity. Parvovirus B19 and adeno-associated virus were found in only 7.5% of the tumors. Taken together, these data suggest that TTV infection is unlikely to be associated with the induction or acceleration of the hepatocarcinogenic process in humans.
AB - A small percentage of persons with hepatocellular carcinoma (HCC) lack identifiable causes of liver pathology. The single-stranded DNA virus, TT virus (TTV), has been found in persons with acute and chronic liver injury. Nested polymerase chain reaction was used to search for both TTV and parvoviruses in 293 HCC samples from Asia and Europe. TTV was found in >30% of Chinese and Italian samples but in only 13% of French samples. No clinicopathologic differences were found between TTV-positive and -negative populations. A significant association was found between TTV infection and hepatitis B virus (P <.01) and herpesviruses (P <.02) in HCC patients, suggesting that factors promoting these infections are associated with enhanced TTV positivity. Parvovirus B19 and adeno-associated virus were found in only 7.5% of the tumors. Taken together, these data suggest that TTV infection is unlikely to be associated with the induction or acceleration of the hepatocarcinogenic process in humans.
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U2 - 10.1086/315321
DO - 10.1086/315321
M3 - Article
C2 - 10720542
AN - SCOPUS:0034078390
VL - 181
SP - 1138
EP - 1142
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -