Effect of TT virus infection on hepatocellular carcinoma development

Results of a Euro-Asian survey

Pascal Pineau, Mounira Meddeb, Roberta Raselli, Lun Xiu Qin, Benoît Terris, Zhao You Tang, Pierre Tiollais, Vincenzo Mazzaferro, Anne Dejean

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A small percentage of persons with hepatocellular carcinoma (HCC) lack identifiable causes of liver pathology. The single-stranded DNA virus, TT virus (TTV), has been found in persons with acute and chronic liver injury. Nested polymerase chain reaction was used to search for both TTV and parvoviruses in 293 HCC samples from Asia and Europe. TTV was found in >30% of Chinese and Italian samples but in only 13% of French samples. No clinicopathologic differences were found between TTV-positive and -negative populations. A significant association was found between TTV infection and hepatitis B virus (P <.01) and herpesviruses (P <.02) in HCC patients, suggesting that factors promoting these infections are associated with enhanced TTV positivity. Parvovirus B19 and adeno-associated virus were found in only 7.5% of the tumors. Taken together, these data suggest that TTV infection is unlikely to be associated with the induction or acceleration of the hepatocarcinogenic process in humans.

Original languageEnglish
Pages (from-to)1138-1142
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number3
DOIs
Publication statusPublished - 2000

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Torque teno virus
Virus Diseases
Hepatocellular Carcinoma
Parvovirus
Dependovirus
DNA Viruses
Herpesviridae
Single-Stranded DNA
Liver
Surveys and Questionnaires
Hepatitis B virus
Pathology
Polymerase Chain Reaction
Wounds and Injuries

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Pineau, P., Meddeb, M., Raselli, R., Qin, L. X., Terris, B., Tang, Z. Y., ... Dejean, A. (2000). Effect of TT virus infection on hepatocellular carcinoma development: Results of a Euro-Asian survey. Journal of Infectious Diseases, 181(3), 1138-1142. https://doi.org/10.1086/315321

Effect of TT virus infection on hepatocellular carcinoma development : Results of a Euro-Asian survey. / Pineau, Pascal; Meddeb, Mounira; Raselli, Roberta; Qin, Lun Xiu; Terris, Benoît; Tang, Zhao You; Tiollais, Pierre; Mazzaferro, Vincenzo; Dejean, Anne.

In: Journal of Infectious Diseases, Vol. 181, No. 3, 2000, p. 1138-1142.

Research output: Contribution to journalArticle

Pineau, P, Meddeb, M, Raselli, R, Qin, LX, Terris, B, Tang, ZY, Tiollais, P, Mazzaferro, V & Dejean, A 2000, 'Effect of TT virus infection on hepatocellular carcinoma development: Results of a Euro-Asian survey', Journal of Infectious Diseases, vol. 181, no. 3, pp. 1138-1142. https://doi.org/10.1086/315321
Pineau, Pascal ; Meddeb, Mounira ; Raselli, Roberta ; Qin, Lun Xiu ; Terris, Benoît ; Tang, Zhao You ; Tiollais, Pierre ; Mazzaferro, Vincenzo ; Dejean, Anne. / Effect of TT virus infection on hepatocellular carcinoma development : Results of a Euro-Asian survey. In: Journal of Infectious Diseases. 2000 ; Vol. 181, No. 3. pp. 1138-1142.
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