Effect of two prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, on plasma ACTH and cortisol levels in man

F. Cavagnini, A. Di Landro, C. Maraschini, C. Invitti, M. L. Pinto

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26 Citations (Scopus)

Abstract

The aim of this study was to investigate the possible role of prostaglandins (PG) in the control of the hypothalamic-pituitary-adrenocortical axis in normal volunteers. Acute oral administration of 100 mg indomethacin (ID) or 1.5 g acetylsalicylic acid (ASA) did not alter ACTH and cortisol plasma levels. Administration of 300 mg daily ID for 4 days delayed the onset, but increased the magnitude, of the response of ACTH to insulin hypoglycaemia, while it blunted the cortisol response. Administration of 3.2 g ASA daily depressed ACTH response to hypoglycaemia leaving the cortisol response unchanged, except for a 15 min delay in onset. These results are interpreted assuming that ID and ASA chiefly acted at the pituitary and hypothalamic level, respectively, and that ID, but not ASA, interfered with adrenocortical cortisol production. The authors' findings support the concept, based on animal studies, that PG enhance hypothalamic CRF release and adrenocortical steroidogenesis and may restrain ACTH secretion in the pituitary.

Original languageEnglish
Pages (from-to)666-673
Number of pages8
JournalActa Endocrinologica
Volume91
Issue number4
Publication statusPublished - 1979

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Prostaglandin Antagonists
Indomethacin
Adrenocorticotropic Hormone
Aspirin
Hydrocortisone
Hypoglycemia
Prostaglandins
Oral Administration
Healthy Volunteers
Insulin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of two prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, on plasma ACTH and cortisol levels in man. / Cavagnini, F.; Di Landro, A.; Maraschini, C.; Invitti, C.; Pinto, M. L.

In: Acta Endocrinologica, Vol. 91, No. 4, 1979, p. 666-673.

Research output: Contribution to journalArticle

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