EFFETTO DELL'ACIDO URSODESOSSICOLICO IN PAZIENTI CON CIRROSI EPATICA ED IPERTRANSAMINASEMIA CRONICA

Translated title of the contribution: Effect of ursodeoxycholic acid in cirrhotic patients with chronic hypertransaminasemia

G. Buongiorno, G. M. Quaranta, A. Penna, V. Guerra, G. Misciagna, O. G. Manghisi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to evaluate the effect of ursodeoxycholic acid (UDCA) oral administration on alanine aminotransferases (ALT) levels in cirrhotic patients with chronic hypertransaminasemia. Ninety consecutive patients with histologically proven liver cirrhosis and ALT levels higher than twice the upper limit of normal for at least six months, were admitted to the study. All the patients were treated with UDCA 10 mg/kg/day for one year. At the end of this period they were randomized to placebo or to continue UDCA therapy for three further months. ALT levels were evaluated before the beginning of UDCA therapy, at twelve and fifteen months by standard methods. After 12 months of UDCA, ALT decreased significantly (-39 UI, 95% confidence intervals -27 to -52 UI). At the 15th month ALT did not vary with respect to its values at the 12th month in 36 patients randomized to continue UDCA, while it increased significantly in patients taking the placebo (+11 UI 95% confidence intervals +2 to +19). The results of this study suggest that UDCA is effective in controlling the biochemical activity of the liver disease in cirrhotic patients.

Translated title of the contributionEffect of ursodeoxycholic acid in cirrhotic patients with chronic hypertransaminasemia
Original languageItalian
Pages (from-to)31-36
Number of pages6
JournalMinerva Gastroenterologica e Dietologica
Volume40
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Gastroenterology

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