Effect of valproate on free plasma phenytoin concentrations.

LM Tsanaclis, J. Allen, E. Perucca, PA Routledge, A. Richens

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The plasma protein binding of phenytoin was studied in nine epileptic patients before and during addition of sodium valproate to the drug therapy. The free phenytoin fraction in plasma was significantly greater during sodium valproate treatment. The mean free fraction rose from 0.135 +/‐ 0.019 (s.d.) to 0.182 +/‐ 0.030. Total plasma phenytoin concentration fell significantly from a range of 4.3‐26.2 micrograms/ml to 3.4‐19.8 micrograms/ml during sodium valproate treatment. Neither the free plasma concentration nor the saliva concentration of phenytoin was significantly altered by sodium valproate. No significant correlation was found between plasma valproic acid concentrations and the change in phenytoin binding. We conclude that valproic acid displaces phenytoin from plasma protein binding sites but does not inhibit its metabolism. 1984 The British Pharmacological Society

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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