The single oral dose pharmacokinetics of carbamazepine-10,11-epoxide (CBZ-E) were investigated in six normal volunteers during a control session and during concurrent treatment with valpromide (VPM) (300 mg twice daily for 8 days). VPM caused a prolongation of the CBZ-E half-life from 6.4 ± 1.4 to 20.5 ± 6.3 h and decreased CBZ-E clearance from 73.5 ± 20.0 to 23.5 ± 4.0 ml h-1 kg-1 (P <0.01). These results suggest that the elevation of plasma CBZ-E levels in patients receiving carbamazepine and VPM in combination is due to inhibition of epoxide hydrolase in the liver.
|Number of pages||3|
|Journal||British Journal of Clinical Pharmacology|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)