Effect of valpromide on the pharmacokinetics of carbamazepine-10,11-epoxide

F. Pisani, A. Fazio, G. Oteri, E. Spina, E. Perucca, L. Bertilsson

Research output: Contribution to journalArticlepeer-review


The single oral dose pharmacokinetics of carbamazepine-10,11-epoxide (CBZ-E) were investigated in six normal volunteers during a control session and during concurrent treatment with valpromide (VPM) (300 mg twice daily for 8 days). VPM caused a prolongation of the CBZ-E half-life from 6.4 ± 1.4 to 20.5 ± 6.3 h and decreased CBZ-E clearance from 73.5 ± 20.0 to 23.5 ± 4.0 ml h-1 kg-1 (P <0.01). These results suggest that the elevation of plasma CBZ-E levels in patients receiving carbamazepine and VPM in combination is due to inhibition of epoxide hydrolase in the liver.

Original languageEnglish
Pages (from-to)611-613
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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